Poly(DL‑lactide) (PDLLA, MW 100‑200K) is ultra‑high‑molecular‑weight amorphous biodegradable aliphatic polyester derived from ring‑opening polymerization of racemic D,L‑lactide. Random D‑ and L‑lactide repeating units disrupt chain regularity and eliminate crystallinity, representing a stark contrast to semi‑crystalline PLLA homopolymer. This ultra‑high‑MW PDLLA exhibits superior mechanical strength, high toughness and excellent film‑forming property, accompanied by extremely slow homogeneous hydrolytic degradation. Its fully amorphous microstructure allows even water diffusion throughout polymer bulk, enabling sustained degradation and drug release over more than half‑a‑year. Degradation yields endogenous lactic acid which can be metabolized and eliminated in vivo with good biosafety. It is mainly applied in high‑performance absorbable polymer prototypes, structural implant biomaterials and long‑cycle tissue‑engineering research.
Key Features
- MW: 100000‑200000 Da, fully amorphous poly(DL‑lactide), no melting point; glass transition temperature Tg ≈54‑64 °C
- Amorphous microstructure achieves uniform water infiltration and homogeneous hydrolytic degradation, avoiding uneven degradation induced by crystalline domains
- Ultra‑high mechanical strength and toughness; suitable for hot‑press molding, solvent casting, electrospinning and other polymer processing techniques
- Excellent biocompatibility; degradation metabolite is endogenous lactic acid
- Soluble in DCM, CHCl₃, THF, DMF; insoluble in water, alcohols and aliphatic alkanes
- Highly hygroscopic material; ester bonds are extremely sensitive to moisture‑mediated hydrolysis; strict moisture‑proof operation is required
Applications
- Raw polymer for manufacturing high‑strength thick‑wall implant depots and large‑size structural scaffolds for ultra‑long‑term drug‑delivery research
- Fabrication of high‑toughness dense biodegradable films and electrospun membranes for long‑term tissue‑engineering research
- Prepolymer source for synthesizing ultra‑high‑molecular‑weight functional PDLLA derivatives
- Research‑grade material for developing high‑performance absorbable medical device prototypes
Handling & Storage
- Store at −20 °C under dry sealed condition; strictly moisture‑proof; prevent sharp temperature‑humidity fluctuations
- Fully equilibrate container to ambient temperature before opening package to avoid condensation‑water contamination
- Hermetically seal after partial sampling; repeated freeze‑thaw cycles are strictly prohibited
- For research‑only use; not intended for direct clinical or diagnostic applications
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.