α‑Hydroxyl‑ω‑Amine‑poly(L‑lactide) (PLLA‑NH₂, MW 2K) is linear, mono‑amine‑terminated semi‑crystalline biodegradable aliphatic polyester. The polymer backbone consists of optically pure L‑lactide repeating units, exhibiting regular stereostructure and moderate crystallinity. As low‑molecular‑weight amine‑functional PLLA derivative, this 2 kDa grade has low hydrophobicity and relatively fast hydrolytic degradation behavior. One polymer terminus bears nucleophilic primary amine (‑NH₂) group, the opposite terminus retains inert hydroxyl (‑OH). Terminal amine can form stable amide bonds with carboxyl‑containing molecules under EDC/NHS activation, and react with NHS‑ester, aldehyde, isocyanate and epoxy groups, enabling covalent bioconjugation with peptides, proteins and targeting ligands. It acts as monofunctional macromolecular initiator and modification building block for fast‑degrading nanoparticle preparation, surface functionalization and biomedical delivery research.
Key Features
- MW: 2000 Da, linear α‑hydroxyl‑ω‑amine‑terminated poly(L‑lactide)
- Semi‑crystalline structure derived from L‑lactide stereoregularity, distinct from fully‑amorphous PDLLA
- Low hydrophobicity, relatively fast and uniform hydrolytic degradation versus higher‑MW PLLA‑NH₂ homologues
- Good biocompatibility; degrades into non‑toxic L‑lactic‑acid metabolites in vitro and in vivo
- Single terminal primary amine (‑NH₂) group; high nucleophilic reactivity for amide coupling and multiple organic reactions; opposite polymer end is inert hydroxyl ‑OH
- Narrow molecular‑weight distribution, stable batch‑to‑batch reproducibility; high amine end‑group functionality
- Soluble in DCM, CHCl₃, THF, DMF, acetone; insoluble in water
- Amine group is moisture‑sensitive; avoid prolonged exposure to humid air and acidic contaminants
Applications
- Monofunctional building block for amide‑based bioconjugation with carboxyl‑bearing peptides, proteins and targeting moieties
- Macro‑initiator for ring‑opening polymerization of NCA monomers to synthesize PLLA‑based block copolymers
- Fabrication of amine‑functional fast‑degrading PLLA nanoparticles and micelles for drug‑delivery research
- Surface amino‑modification of polyester biomaterials to improve cell affinity
- Research‑grade raw material for constructing degradable biomedical polymer conjugates
Handling & Storage
- Store at −20 °C under dry inert nitrogen or argon atmosphere; strictly moisture‑proof
- Keep hermetically sealed; humidity may deactivate amine end‑groups and accelerate polyester hydrolysis; avoid repeated freeze‑thaw cycles
- For research‑only use; not intended for clinical or diagnostic applications
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.