PDLLA-Biotin (PDLLA-Bio), MW 5K is a biotin-functionalized poly(DL-lactide) with a molecular weight of approximately 5K. It combines a low-molecular-weight, biodegradable amorphous PDLLA backbone with terminal biotin functionality specifically for avidin-biotin binding, bioconjugation, surface modification, nanoparticle functionalization, and biomaterial research.
Key Features and Benefits
- Biotin-Functionalized PDLLA: Combines biodegradable poly(DL-lactide) with a terminal biotin group for affinity-based binding and functionalization.
- MW 5K: Provides a low molecular weight with good processability specifically for polymer formulation, functionalization, and conjugation research.
- Biotin Functionality: The terminal biotin group provides a high-affinity recognition site specifically for avidin, streptavidin, and related biotin-binding proteins.
- Biodegradable Polyester: The PDLLA backbone contains hydrolyzable ester linkages that specifically support gradual polymer degradation under appropriate conditions.
- Amorphous PDLLA Backbone: The random distribution of D- and L-lactide units limits crystallization and provides an amorphous polymer structure.
- Good Processability: The lower molecular weight facilitates polymer dissolution, formulation, and functionalization compared with higher-molecular-weight PDLLA grades.
- Affinity-Based Conjugation: Biotin functionality supports noncovalent assembly with streptavidin- or avidin-containing molecules, surfaces, and materials.
Applications
- Avidin-Biotin Binding: Supports high-affinity interactions with avidin, streptavidin, and related biotin-binding proteins.
- Bioconjugation: Enables affinity-based attachment of PDLLA to compatible biotin-binding biomolecules and functional components.
- Nanoparticle Functionalization: Supports preparation and surface functionalization of biodegradable polymer nanoparticles for affinity-based research.
- Surface Modification: Enables incorporation of biotin functionality into PDLLA-containing surfaces, coatings, and materials.
- Affinity Capture: Supports development of polymer systems for affinity binding, immobilization, and capture studies.
- Drug Delivery: Supports development of functional biodegradable polymer systems for drug-delivery and controlled-release research.
- Polymer Functionalization: Provides a biotin-functionalized PDLLA platform for preparing multicomponent and affinity-based polymer systems.
- Biomaterial Research: Supports development of functional biodegradable polymers, particles, coatings, composites, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions. Protect from moisture and excessive heat.
- Handling: Protect from moisture and excessive heat. Allow the material to equilibrate to room temperature before opening to minimize moisture condensation.
PDLLA-Biotin (PDLLA-Bio), MW 5K provides a low-molecular-weight, amorphous biodegradable PDLLA platform with terminal biotin functionality and good processability and specifically supports avidin-biotin interactions, bioconjugation, nanoparticle functionalization, surface modification, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.