α‑Hydroxyl‑ω‑biotin‑poly(D,L‑lactide) (PDLLA‑Biotin, MW 20K) is linear, mono‑biotin‑terminated fully amorphous biodegradable aliphatic polyester. D‑lactide and L‑lactide repeat units are randomly distributed along polymer backbone, disrupting stereoregularity and eliminating crystalline domains. Within the PDLLA‑Biotin product series, this 20 kDa grade possesses the highest hydrophobicity and exhibits extremely slow yet homogeneous hydrolytic degradation. One chain terminus carries reactive biotin (vitamin H), the opposite end retains inert hydroxyl (‑OH). Terminal biotin enables high‑affinity specific binding with avidin / streptavidin, widely applied for biomolecule immobilization, ligand capture and targeted bioconjugation. It serves as a monofunctional macro‑monomer for nanoparticle surface modification, biosensing and ultra‑long‑term sustained‑release targeted drug‑delivery biomedical research.
Key Features
- MW: 20000 Da, linear α‑hydroxyl‑ω‑biotin‑terminated poly(D,L‑lactide)
- Fully amorphous non‑crystalline structure, random D/L‑lactide sequence, no melting point
- Highest hydrophobicity in PDLLA‑Biotin portfolio, ultra‑slow but uniform hydrolytic degradation
- Excellent biocompatibility; degradation produces non‑toxic lactic‑acid metabolites
- Single reactive biotin terminus; high‑affinity binding to avidin/streptavidin; opposite end is inert hydroxyl ‑OH
- Narrow molecular‑weight distribution, stable batch‑to‑batch reproducibility
- Soluble in DCM, CHCl₃, THF, DMF, hot acetone; insoluble in water
- Biotin moiety is light‑sensitive; avoid prolonged light exposure and high‑temperature conditions
Applications
- Monofunctional building block for avidin‑biotin mediated bioconjugation of peptides, antibodies, targeting ligands and fluorescent probes
- Biotin‑functional surface modification of PDLLA‑based nanoparticles and microspheres for ultra‑long‑term sustained‑release study
- Precursor for biosensor construction and biomolecule immobilization onto high‑molecular‑weight dense biodegradable polyester films and implant substrates
- Research‑grade raw material for preparing avidin‑mediated long‑circulating targeted drug‑delivery carriers
Handling & Storage
- Store at −20 °C under dry inert nitrogen or argon atmosphere; strictly moisture‑proof, protected from light
- Keep hermetically sealed; moisture and heat may trigger ester hydrolysis and impair biotin activity; avoid repeated freeze‑thaw cycles
- For research‑only use; not intended for clinical or diagnostic applications
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.