α‑Hydroxyl‑ω‑azido‑poly(D,L‑lactide) (PDLLA‑N₃, MW 20K) is linear, mono‑azido‑terminated fully amorphous biodegradable aliphatic polyester. D‑lactide and L‑lactide repeat units are randomly distributed along polymer backbone, disrupting stereoregularity and eliminating crystalline domains. Within the PDLLA‑Azide product series, this 20 kDa grade possesses the highest hydrophobicity and exhibits extremely slow yet homogeneous hydrolytic degradation. One chain terminus carries reactive azide (‑N₃), the opposite end retains inert hydroxyl (‑OH). Terminal azide participates in bioorthogonal click chemistry, including copper‑catalyzed azide‑alkyne cycloaddition (CuAAC) and copper‑free strain‑promoted azide‑alkyne cycloaddition (SPAAC) with DBCO / BCN moieties to form stable triazole linkages. It serves as a monofunctional macro‑monomer for bioconjugation, nanoparticle surface functionalization and post‑polymerization modification for ultra‑long‑term sustained‑release biomedical research.
Key Features
- MW: 20000 Da, linear α‑hydroxyl‑ω‑azido‑terminated poly(D,L‑lactide)
- Fully amorphous non‑crystalline structure, random D/L‑lactide sequence, no melting point
- Highest hydrophobicity in PDLLA‑Azide portfolio, ultra‑slow but uniform hydrolytic degradation
- Excellent biocompatibility; degradation produces non‑toxic lactic‑acid metabolites
- Single reactive‑N₃ terminus; compatible with CuAAC & SPAAC click reactions; opposite end is inert hydroxyl ‑OH
- Narrow molecular‑weight distribution, stable batch‑to‑batch reproducibility
- Soluble in DCM, CHCl₃, THF, DMF, hot acetone; insoluble in water
- Azide end‑group is light‑sensitive; avoid prolonged light exposure and high‑temperature conditions
Applications
- Monofunctional building block for click‑bioconjugation with alkyne‑/DBCO‑activated peptides, targeting ligands and fluorescent dyes
- Azide‑functional surface modification of PDLLA‑based nanoparticles and microspheres for ultra‑long‑term sustained‑release study
- Precursor for post‑modification of high‑molecular‑weight dense biodegradable polyester films and implant materials
- Research‑grade raw material for constructing bioorthogonal long‑circulating drug‑delivery carriers
Handling & Storage
- Store at −20 °C under dry inert nitrogen or argon atmosphere; strictly moisture‑proof, protected from light
- Keep hermetically sealed; moisture and heat may trigger ester hydrolysis and impair azide activity; avoid repeated freeze‑thaw cycles
- For research‑only use; not intended for clinical or diagnostic applications
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.