As the ultra‑high‑molecular‑weight flagship grade of the PCL‑Amine series, this 20 kDa amine‑terminated poly(ε‑caprolactone) exhibits dense chain packing and maximum crystallinity compared with all lower‑molecular‑weight counterparts. Its terminal primary amine groups are available for EDC/NHS‑mediated amide bond formation with carboxyl‑functionalized peptides, growth factors and solid substrate surfaces. Owing to extensive intermolecular chain entanglement, hydrolytic degradation proceeds over a multi‑month timescale, and processed solid constructs can sustain implant‑relevant mechanical loads within subcutaneous tissue microenvironments. Unlike medium‑molecular‑weight variants designed for circulating nanoparticles, this polymer is predominantly tailored for solid implant and scaffold‑oriented workflows, where long‑term mechanical robustness and post‑fabrication covalent bio‑modification represent core experimental objectives.
Key Features: ‑ Ultra‑high‑molecular‑weight highly crystalline PCL backbone end‑capped with primary amine groups; dense chain entanglement delivers exceptional mechanical toughness for implant‑oriented polymer constructs ‑ Multi‑month ultra‑slow hydrolytic degradation profile; maintains complete structural integrity throughout prolonged in‑vivo implant cycles before gradual bulk matrix erosion ‑ Retains amine‑group reactivity for EDC/NHS‑driven amide conjugation, enabling surface bio‑functionalization even for high‑crystallinity compact electrospun scaffolds ‑ Favourable processability for electrospinning and solvent casting; generates dimension‑resilient fibrous scaffolds and implant membranes resistant to deformation in tissue‑related microenvironments ‑ Spectroscopically validated amine end‑group conversion; tightly controlled residual monomer and catalyst levels suitable for advanced implant‑focused pre‑clinical laboratory research
Applications: ‑ EDC/NHS‑activated bio‑functionalized electrospun implant scaffolds for covalent immobilization of carboxyl‑rich bioactive factors in multi‑month tissue‑engineering research ‑ Fabrication of surface‑tunable solid polymer implant prototypes requiring multi‑month mechanical persistence and site‑specific biomolecule immobilization ‑ Development of local long‑acting drug‑release implant devices where scaffold structural integrity must persist across multi‑month in‑vivo observation windows ‑ Preparation of amide‑linked polymer‑biomolecule conjugates optimized for implant‑tissue interface remodelling, rather than intravenous circulating nanoparticle scenarios ‑ Pre‑screening of implant‑grade amine‑terminated polyesters for translational pre‑clinical research pipelines
Handling & Storage: Store lyophilized polymer powder at −20 °C under dry inert‑gas atmosphere. Primary amine termini readily react with ambient carbon dioxide to produce carbamate impurities that compromise bioconjugation performance; moisture further accelerates impurity generation and random ester‑chain hydrolysis. Place sealed vials inside a desiccator and achieve full room‑temperature thermal equilibration prior to opening to prevent water‑vapour‑induced sample contamination. Prepare working solutions exclusively with anhydrous organic solvents immediately before experimental manipulation; long‑term storage of pre‑dissolved polymer stock solutions is not recommended. This product is for laboratory research only and has not been authorized for human clinical use.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.