Positioned between high‑molecular‑weight 10K and ultra‑high‑molecular‑weight 20K PCL‑Amine, this 15 kDa amine‑terminated poly(ε‑caprolactone) features further elongated polyester chains, enhanced intermolecular chain entanglement and higher crystallinity. Its terminal primary amine groups can be activated for EDC/NHS‑mediated amide bond formation with carboxyl‑containing peptides, growth factors and bioactive substrates. The hydrolytic degradation characteristic falls within weeks‑to‑early‑multi‑month timescale, delivering superior mechanical performance compared to 10K grade without reaching the extreme erosion resistance of 20K. Optimized for semi‑implant‑relevant experimental scenarios, this polymer combines cationic surface‑tunable properties and EDC/NHS bioconjugation capability with prolonged structural stability for intermediate implant‑mimicking pre‑clinical evaluation.
Key Features: ‑ Mid‑ultra‑high‑molecular‑weight PCL backbone with terminal primary‑amine functionality, achieving improved mechanical strength relative to 10K and lower‑molecular‑weight PCL‑Amine grades ‑ Weeks‑to‑early‑multi‑month degradation profile; retains structural integrity under biological microenvironments throughout extended pre‑clinical cycles prior to gradual bulk erosion ‑ Balanced solubility‑rigidity performance; soluble in common anhydrous organic solvents while generating mechanically stable nanoparticles and electrospun semi‑implantable membranes ‑ End‑group‑originated positive surface potential enables flexible modulation of cell‑particle interaction and biomaterial‑tissue interface behaviours ‑ Spectroscopically verified amine end‑group conversion rate; strictly controlled residual impurity levels compatible with advanced cell assays and semi‑implant‑oriented small‑animal model evaluation
Applications: ‑ Fabrication of highly stable amine‑labelled cationic nanoparticles and micelles for long‑term drug release and prolonged in‑vivo biodistribution monitoring after EDC/NHS ligand conjugation ‑ EDC/NHS‑driven surface bio‑functionalization of semi‑implantable electrospun membranes for medium‑to‑long‑term tissue‑integration research ‑ Synthesis of amide‑linked polymer‑biomolecule conjugates for durable targeting systems applied in subcutaneous small‑animal studies ‑ Formulation development bridging long‑circulating nanocarriers and full implant‑grade ultra‑high‑MW PCL‑Amine materials ‑ Prototype assessment of cationic polyester platforms for translational pre‑clinical pipelines prior to adopting 20K ultra‑slow‑degrading polymer grades
Handling & Storage: Store lyophilized polymer powder at −20 °C under dry inert‑gas environment. Primary amine termini readily react with ambient carbon dioxide to generate carbamate impurities and reduce coupling activity; moisture further accelerates impurity formation and random ester‑chain hydrolysis. Keep sealed vials within a desiccator and achieve full room‑temperature equilibration before opening to avoid water‑vapour‑triggered sample contamination. Prepare fresh working solutions using anhydrous organic solvents immediately before experimental operations; long‑term preservation of dissolved polymer stock solutions is discouraged. This product is intended solely for laboratory research and is not eligible for human clinical usage.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.