PLGA SH Capped, MW 40K is a premium ultra-high-molecular-weight, thiol-terminated reactive biodegradable PLGA copolymer, representing the highest stability grade in the entire PLGA-SH product series. Engineered for multi-year permanent thiol-specific bioconjugation, ultra-tough implantable nanoparticle fabrication, and multi-year ultra-long-acting sustained drug delivery, this polymer features maximum compact chain entanglement, top-tier mechanical toughness, and multi-year slow hydrolytic degradation kinetics. It maintains stable terminal thiol reactivity throughout extreme long-term in vivo erosion cycles, serving as a clinical-grade premium reactive building block for translational implantable devices and multi-year long-cycle biomedical research.
Basic Specifications
Alternative Name: PLGA-SH, Thiol-terminated PLGA
Polymer Composition: Poly(lactic-co-glycolic acid)-Thiol
Molecular Weight: Custom molecular weights available
Lactide:Glycolide Ratio: 65:35, 75:25, 85:15, Custom synthesis
Functional Groups: Thiol (SH)
Appearance: White to off-white solid
Key Features and Benefits
Highly Active Terminal Thiol (SH) Reactivity: Modified with high-purity terminal thiol functional groups, enabling ultra-high-specificity, permanent covalent conjugation with maleimide, vinyl sulfone, gold nanoparticles and disulfide bonds under mild physiological conditions. It delivers high-yield, zero-background bioconjugation with persistent activity that endures multi-year degradation cycles, supporting permanent covalent modification of high-value antibodies, clinical-grade therapeutic proteins, long-acting peptides and targeted ligands for ultra-long-term implantable biomedical research.
Tunable Lactide-Glycolide Ratio System: Covers all mainstream industrial ratios including 65:35, 75:25, 85:15, and supports fully personalized custom synthesis. Precision ratio adjustment flexibly modulates polymer hydrophobicity, multi-year ultra-slow degradation kinetics and maximum mechanical strength, perfectly matching multi-year implantable sustained-release formulations and high-rigidity clinical biomaterial modification scenarios.
Top-Tier 40K Ultra-High Molecular Weight Performance: As the highest molecular weight specification in the PLGA-SH series, the 40K grade forms extremely compact and dense polymer chain entanglement, delivering industry-maximum structural rigidity, anti-aging toughness and permanent morphological stability. It possesses the slowest, most uniform degradation profile among all PLGA-SH variants, completely eliminating particle deformation, structural fatigue and premature drug leakage, exclusively tailored for multi-year implantable delivery systems and ultra-durable carrier fabrication.
Clinical-Grade Biocompatibility & Multi-Year Mild Degradation: Features premium clinical-grade physiological biocompatibility and biosafety. The high-purity PLGA backbone undergoes gradual, mild and homogeneous hydrolysis into endogenous non-toxic lactic acid and glycolic acid over multi-year in vivo cycles. Terminal thiol groups exhibit negligible biological irritation, triggering no inflammation, immune rejection or residual toxicity, fully complying with clinical implantation standards and high-level translational medical research requirements.
Multi-Year Permanent Conjugation Stability: Advanced precision terminal SH single-point capping technology ensures uniform reactive group distribution and permanent long-term activity retention. The formed covalent linkage exhibits extreme chemical inertness and anti-aging performance, resisting dissociation and functional attenuation during multi-year polymer erosion. It permanently preserves the biological activity of conjugated biomolecules, delivering ultra-stable, repeatable results for clinical-grade long-cycle implantable formulations.
Applications
Multi-Year Permanent Thiol-Specific Bioconjugation: Ideal for permanent covalent immobilization and functional modification of high-value maleimide-activated biomolecules, gold nanocarriers, therapeutic antibodies and long-acting protein drugs, supporting the construction of multi-year stable targeted delivery platforms and clinical-grade biomedical probes.
Multi-Year Ultra-Long Implantable Drug Delivery: Exclusively optimized for ultra-long-acting implantable drug delivery devices and multi-year controlled-release formulations, breaking the cycle limitations of conventional low/medium/high MW PLGA materials, perfectly applicable for long-term chronic disease intervention and clinical long-acting pharmaceutical development.
Permanent Ultra-Tough Implantable Nanoparticle Functionalization: Serves as a top-tier thiol-reactive precursor for clinical-grade implantable carrier surface engineering, providing stable long-term SH active sites for post-synthesis ligand grafting, achieving multi-year in vivo structural stability, persistent circulation retention and permanent targeted enrichment performance.
Multi-Year Durable Implantable Biomedical Engineering: Widely applied for functional crosslinking and surface modification of multi-year degradable high-toughness hydrogels and implantable tissue engineering scaffolds, supporting the development of long-service-life intelligent biomedical materials and clinical implantable therapeutic devices.
Storage and Handling
Storage: Store at –20 °C in a fully sealed, dry, oxygen-free and moisture-proof container. Inert gas sealing is strongly recommended for long-term storage to prevent thiol oxidation and disulfide crosslinking, preserving polymer reactive activity and structural integrity.
Handling: Avoid oxygen exposure, moisture intrusion, high-temperature environments and prolonged air contact to prevent thiol group oxidation and deactivation. Avoid repeated freeze-thaw cycles to maintain stable conjugation efficiency.
PLGA SH Capped, MW 40K integrates permanent terminal thiol reactivity, top-tier ultra-high structural rigidity, tunable ultra-long degradation performance and multi-year hydrolytic kinetics, serving as a premium clinical-grade thiol-reactive biodegradable polymer for multi-year permanent bioconjugation, ultra-long-acting implantable targeted drug delivery and multi-year durable biomedical material modification research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.