PLGA SH Capped, MW 20K is an ultra-high-molecular-weight, thiol-terminated reactive biodegradable PLGA copolymer designed for ultra-durable thiol-specific bioconjugation, ultra-long-cycle implantable nanoparticle functionalization, and multi-month sustained targeted drug delivery research. Featuring ultra-rigid structural toughness, exceptional morphological durability and ultra-slow uniform hydrolytic degradation kinetics, this polymer retains highly active terminal thiol functional groups. It serves as a premium implantable-grade reactive building block for long-term sulfhydryl click chemistry, persistent biomolecule immobilization, and ultra-long-cycle advanced biomedical material modification.
Basic Specifications
Alternative Name: PLGA-SH, Thiol-terminated PLGA
Polymer Composition: Poly(lactic-co-glycolic acid)-Thiol
Molecular Weight: Custom molecular weights available
Lactide:Glycolide Ratio: 65:35, 75:25, 85:15, Custom synthesis
Functional Groups: Thiol (SH)
Appearance: White to off-white solid
Key Features and Benefits
Highly Active Terminal Thiol (SH) Reactivity: Functionalized with high-purity terminal thiol groups, enabling ultra-stable, high-specificity covalent conjugation with maleimide, vinyl sulfone, gold nanoparticles and disulfide bonds under mild physiological conditions. It achieves high-yield, low-background bioconjugation with persistent long-term activity, supporting ultra-durable modification of high-value antibodies, therapeutic proteins, functional peptides and targeted ligands for multi-month long-cycle biomedical and implantable research.
Tunable Lactide-Glycolide Ratio System: Covers mainstream industrial ratios including 65:35, 75:25, 85:15 and supports full custom synthesis. Precise ratio modulation flexibly regulates polymer hydrophobicity, ultra-long degradation kinetics and mechanical toughness, perfectly adapting to multi-month sustained-release formulations and high-rigidity implantable biomaterial modification scenarios.
Ultra-Stable 20K Ultra-High Molecular Weight Performance: The 20K ultra-high molecular weight forms extremely dense polymer chain entanglement, delivering industry-leading structural rigidity, anti-fatigue performance and morphological stability compared with low, medium and conventional high-MW PLGA. It exhibits uniform, ultra-slow hydrolytic degradation behavior, completely eliminating nanoparticle structural collapse, deformation and premature drug leakage, perfectly suitable for fabricating ultra-stable implantable nanoparticles and microspheres for multi-month long-term sustained delivery systems.
Superior Biocompatibility & Ultra-Long Uniform Degradation: Possesses clinical-grade physiological biocompatibility and biosafety. The PLGA backbone undergoes mild, homogeneous and long-term hydrolysis into non-toxic endogenous lactic acid and glycolic acid over multi-month degradation cycles with no inflammatory stimulation or residual toxicity. Terminal thiol groups feature extremely low biological irritation, fully complying with strict safety standards for ultra-long-term in vivo implantation and translational biomedical applications.
Ultra-Long Stable Conjugation Performance: Precision terminal SH capping technology ensures uniform reactive group distribution and consistent ultra-long-term batch reactivity. The formed covalent linkage delivers excellent chemical inertness and anti-aging properties, effectively preventing biomolecule shedding and functional attenuation during ultra-long polymer degradation, guaranteeing stable and repeatable results for multi-month implantable experiments and long-acting formulations.
Applications
Ultra-Durable Thiol-Specific Bioconjugation: Widely applied for ultra-stable covalent coupling and immobilization of high-value maleimide-modified biomolecules, gold nanoparticles, therapeutic peptides and antibodies, supporting the construction of persistent long-acting targeted delivery platforms and high-end biomedical probes for long-cycle research.
Multi-Month Ultra-Long Sustained Drug Delivery: Optimized for manufacturing ultra-stable implantable PLGA nanoparticles and microspheres, achieving uniform multi-month sustained drug release and stable active targeted delivery, suitable for chronic disease long-acting treatment and ultra-long-term controlled-release formulation development.
Ultra-Stable Implantable Nanoparticle Surface Functionalization: Serves as a premium thiol-reactive precursor for advanced implantable carrier surface engineering, providing abundant active SH sites for post-synthesis ligand grafting, greatly enhancing carrier structural durability, long-term in vivo circulation stability and persistent targeted accumulation efficiency.
Ultra-Long-Term Implantable Biomedical Modification: Applicable for functional crosslinking and surface modification of multi-month degradable hydrogels and implantable tissue engineering scaffolds, supporting the construction of high-toughness durable responsive biomaterials and stable functional interfaces for translational implantable biomedical research.
Storage and Handling
Storage: Store at –20 °C in a fully sealed, dry, oxygen-free and moisture-proof container. Inert gas sealing is strongly recommended for long-term storage to prevent thiol oxidation and disulfide crosslinking, preserving polymer reactive activity and structural integrity.
Handling: Avoid oxygen exposure, moisture intrusion, high-temperature environments and prolonged air contact to prevent thiol group oxidation and deactivation. Avoid repeated freeze-thaw cycles to maintain stable conjugation efficiency.
PLGA SH Capped, MW 20K integrates ultra-durable terminal thiol reactivity, premium structural rigidity, tunable degradation performance and ultra-long hydrolytic kinetics, serving as an implantable-grade thiol-reactive biodegradable polymer for ultra-long-term bioconjugation, multi-month sustained targeted drug delivery and high-durability implantable biomedical material modification research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.