PLGA SH Capped, MW 2K is a low-molecular-weight, thiol-terminated reactive biodegradable PLGA copolymer designed for efficient thiol-specific bioconjugation, rapid nanoparticle surface functionalization, and short-cycle targeted drug delivery research. Featuring excellent organic solubility, fast and uniform hydrolytic degradation, and highly active terminal thiol functional groups, this polymer serves as a versatile reactive building block for sulfhydryl click chemistry, biomolecule immobilization, and fast-response biomedical material modification.
Basic Specifications
Alternative Name: PLGA-SH, Thiol-terminated PLGA
Polymer Composition: Poly(lactic-co-glycolic acid)-Thiol
Molecular Weight: Custom molecular weights available
Lactide:Glycolide Ratio: 65:35, 75:25, 85:15, Custom synthesis
Functional Groups: Thiol (SH)
Appearance: White to off-white solid
Key Features and Benefits
Highly Active Terminal Thiol (SH) Reactivity: Functionalized with high-purity terminal thiol groups, enabling efficient and specific covalent conjugation with multiple reactive groups including maleimide, vinyl sulfone, gold nanoparticles, and disulfide bonds under mild physiological conditions. It achieves high-yield bioconjugation with minimal side reactions, supporting reliable and stable modification of antibodies, peptides, proteins and targeted ligands for short-cycle biomedical research.
Tunable Lactide-Glycolide Ratio System: Covers mainstream industrial ratios of 65:35, 75:25, 85:15 and supports full custom synthesis. Precise ratio adjustment flexibly regulates polymer hydrophobicity, degradation rate and solution solubility, perfectly adapting to diverse fast-degrading formulation requirements and short-term functional modification scenarios.
Superior Low 2K Molecular Weight Properties: The low 2K molecular weight endows the polymer with excellent solubility in common organic solvents, facilitating convenient solution processing, nanoparticle preparation and surface modification. It features rapid, homogeneous hydrolytic degradation, supporting fast carrier erosion and complete cargo release, which is ideal for acute treatment drug delivery and quick biomedical functional assembly.
Excellent Biocompatibility & Clean Fast Degradation: Possesses superior physiological biocompatibility and biosafety. The PLGA backbone gradually hydrolyzes into endogenous non-toxic lactic acid and glycolic acid without inflammatory stimulation or residual toxicity. The terminal thiol group exhibits low biological irritation, fully meeting safety standards for in vitro conjugation experiments and short-term in vivo biomedical applications.
Flexible & Repeatable Bioconjugation Performance: Precise terminal SH capping ensures uniform reactive group distribution and stable batch-to-batch reactivity. The formed covalent linkage features good chemical stability, effectively avoiding biomolecule shedding and functional failure during short-term polymer degradation, ensuring repeatable experimental and formulation results.
Applications
Thiol-Specific Bioconjugation: Widely applied for covalent coupling and immobilization of maleimide-modified biomolecules, gold nanoparticles, functional peptides and therapeutic proteins, supporting efficient construction of targeted drug delivery systems and biomedical probes.
Rapid-Release Targeted Drug Delivery: Optimized for the preparation of fast-degrading PLGA nanoparticles and microspheres, enabling short-cycle uniform drug release and active targeted delivery, suitable for acute disease treatment and rapid therapeutic intervention research.
Nanoparticle Surface Functionalization: Serves as an efficient thiol-reactive precursor for biodegradable carrier surface engineering, providing abundant active SH sites for post-synthesis ligand modification, enhancing carrier targeting specificity and biological adhesion performance.
Short-Cycle Biomedical Material Modification: Suitable for functional crosslinking and surface modification of fast-degrading hydrogels and tissue engineering scaffolds, supporting the construction of responsive biodegradable materials and short-term functional biomedical interfaces.
Storage and Handling
Storage: Store at –20 °C in a fully sealed, dry, oxygen-free and moisture-proof container. Inert gas sealing is strongly recommended for long-term storage to prevent thiol oxidation and disulfide crosslinking, preserving polymer reactive activity and structural integrity.
Handling: Avoid oxygen exposure, moisture intrusion, high-temperature environments and prolonged air contact to prevent thiol group oxidation and deactivation. Avoid repeated freeze-thaw cycles to maintain stable conjugation efficiency.
PLGA SH Capped, MW 2K integrates highly active terminal thiol reactivity, excellent solubility, tunable degradation performance and fast hydrolytic kinetics, serving as a universal thiol-reactive biodegradable polymer for efficient bioconjugation, rapid-release targeted drug delivery and short-cycle biomedical material functional modification research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.