PLGA NHS Capped, MW 5K (PLGA‑NHS) is a medium‑molecular‑weight, amine‑reactive biodegradable PLGA copolymer functionalized with terminal N‑hydroxysuccinimide (NHS) ester groups. Balancing excellent organic solubility, moderate structural rigidity and steady hydrolytic degradation performance, this polymer enables efficient and specific covalent conjugation with amine‑containing biomolecules. It serves as a versatile mainstream reactive building block for medium-cycle sustained drug delivery, stable nanoparticle functionalization and routine biomedical modification research.
Basic Specifications
Alternative Name: PLGA‑NHS, PLGA N‑hydroxysuccinimide Capped
Polymer Composition: Poly(D,L‑lactide‑co‑glycolic acid)‑NHS
Molecular Weight: 5K, Custom
Appearance: White to off‑white solid
Key Features and Benefits
Highly Active Terminal NHS Ester Reactivity: Modified with high-purity terminal NHS ester functional groups, achieving efficient and specific covalent crosslinking with primary amine (-NH₂) groups under mild physiological conditions. The reaction generates stable, irreversible amide bonds with extremely low non-specific adsorption and side reactions, ensuring safe and reliable covalent modification of antibodies, proteins, peptides and amine-terminated targeted ligands.
Balanced 5K Medium Molecular Weight Performance: The standard 5K medium molecular weight optimally balances solubility and structural stability. Compared with low-MW PLGA, it possesses enhanced chain entanglement and morphological stability, delivering uniform and moderate degradation speed. It effectively avoids excessive burst release and structural instability, perfectly suitable for conventional medium-cycle sustained-release formulations and stable nanoparticle preparation.
Excellent Biocompatibility & Uniform Degradation: Features superior physiological biocompatibility and biosafety. The PLGA backbone undergoes slow and uniform hydrolysis into non-toxic endogenous lactic acid and glycolic acid, without inflammatory stimulation, tissue irritation or residual toxicity, fully complying with in vitro conjugation experiments and medium-term in vivo biomedical application standards.
Stable and Repeatable Conjugation Efficiency: Precise terminal NHS capping technology ensures uniform distribution of reactive groups and stable batch activity. The formed amide covalent bond boasts excellent chemical stability, effectively preventing ligand shedding and functional attenuation during polymer degradation, ensuring consistent and repeatable experimental and formulation results.
Universal Functional Modification Compatibility: Amine-specific reaction mechanism supports flexible post-synthesis functionalization of prefabricated nanoparticles and biomedical scaffolds. The mild reaction conditions protect the biological activity of modified molecules and the integrity of carrier morphology, with strong adaptability for routine biomedical research.
Applications
Universal Amine‑Specific Bioconjugation: Widely applied for stable covalent modification and immobilization of amine-rich therapeutic proteins, antibodies, functional peptides and targeted ligands, supporting standardized biomolecule assembly and biomedical probe preparation.
Medium‑Cycle Sustained Targeted Drug Delivery: Ideal for preparing structurally stable PLGA nanoparticles and microspheres, realizing uniform medium-term sustained drug release and active targeted delivery, suitable for conventional disease treatment and routine sustained-release pharmaceutical research.
Stable Nanoparticle Surface Functionalization: Serves as a high-efficiency reactive precursor for biodegradable carrier surface engineering, stably introducing targeting functional groups to enhance carrier specificity, cellular uptake efficiency and in vivo enrichment stability.
Routine Medium‑Term Biomedical Research: Applicable for stable biomaterial modification, medium-cycle sustained-release system construction and biological labeling research, providing reliable reactive performance for daily standardized biomedical experimental workflows.
Storage and Handling
Storage: Store at –20 °C in a fully sealed, dry, moisture‑proof container. Inert gas sealing is strongly recommended for long‑term storage to prevent NHS ester hydrolysis and preserve polymer reactive activity and structural integrity.
Handling: Strictly avoid moisture intrusion, high‑temperature environments and prolonged air exposure, as NHS groups are highly moisture‑sensitive and prone to deactivation. Avoid repeated freeze‑thaw cycles to maintain stable conjugation efficiency.
PLGA NHS Capped, MW 5K balances high amine-specific NHS reactivity, moderate structural rigidity and steady medium-cycle degradability, acting as a versatile standard reactive biodegradable polymer for universal bioconjugation, medium-term sustained targeted drug delivery and routine biomaterial functional modification research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.