PLGA NHS Capped, MW 2K (PLGA‑NHS) is a low‑molecular‑weight, amine‑reactive biodegradable PLGA copolymer functionalized with terminal N‑hydroxysuccinimide (NHS) ester groups. Designed for rapid bioconjugation, fast‑degrading nanoparticle fabrication, and short‑cycle targeted drug delivery, this low‑MW polymer features excellent organic solubility and rapid, uniform hydrolytic degradation. It enables highly efficient, site‑specific covalent coupling with amine‑containing biomolecules, serving as a universal reactive building block for fast biomedical functional modification and acute therapeutic formulation research.
Basic Specifications
Alternative Name: PLGA‑NHS, PLGA N‑hydroxysuccinimide Capped
Polymer Composition: Poly(D,L‑lactide‑co‑glycolic acid)‑NHS
Molecular Weight: 2K, Custom
Appearance: White to off‑white solid
Key Features and Benefits
Highly Active Terminal NHS Ester Reactivity: Functionalized with high‑purity terminal NHS ester groups, enabling rapid and specific covalent conjugation with primary amine (‑NH₂) groups under mild physiological conditions. The reaction produces stable, irreversible amide bonds with minimal non‑specific binding and few side reactions, ensuring efficient and reliable modification of proteins, peptides, antibodies and amine‑terminated ligands.
Low 2K Molecular Weight Advantages: The 2K low molecular weight structure provides exceptional solubility in common organic solvents, facilitating convenient solution processing and nanoparticle preparation. It exhibits fast, homogeneous hydrolytic degradation behavior, supporting rapid carrier erosion, complete cargo release, and short‑term therapeutic action, which is ideal for acute drug delivery scenarios and quick surface functionalization.
Excellent Biocompatibility & Clean Degradation: Possesses superior physiological biocompatibility and biosafety. The PLGA backbone gradually hydrolyzes into endogenous non‑toxic lactic acid and glycolic acid without inflammatory stimulation or residual toxicity, fully meeting safety requirements for in vitro bioconjugation experiments and short‑term in vivo biomedical applications.
High‑Efficiency Repeatable Conjugation: Precise terminal NHS capping ensures consistent reactive group loading and stable batch‑to‑batch reactivity. The formed amide covalent linkage features outstanding chemical stability, effectively preventing biomolecule shedding and functional failure during polymer degradation, guaranteeing repeatable experimental results.
Convenient Post‑Modification Compatibility: The amine‑specific reaction mechanism allows flexible post‑synthesis functionalization of preformed nanoparticles and biomaterials, avoiding harsh reaction conditions that may damage biological activity or particle morphology.
Applications
Amine‑Specific Bioconjugation: Widely utilized for covalent modification and immobilization of amine‑rich proteins, antibodies, peptides, enzymes and amine‑terminated targeting ligands, supporting stable biomolecular assembly and biomedical probe preparation.
Rapid‑Release Targeted Drug Delivery: Optimized for the preparation of fast‑degrading PLGA nanoparticles and microspheres, enabling short‑cycle controlled drug release and active targeted delivery for acute disease treatment and rapid therapeutic intervention research.
Biomaterial Surface Functionalization: Serves as an efficient reactive precursor for surface engineering of biodegradable carriers and scaffolds, rapidly introducing targeting moieties and functional biomolecules to enhance carrier specificity and biological performance.
Short‑Cycle Biomedical Functional Research: Suitable for quick biomaterial modification, transient drug delivery systems and short‑term biological labeling studies, providing reliable reactive performance for fast‑paced biomedical experimental workflows.
Storage and Handling
Storage: Store at –20 °C in a fully sealed, dry, moisture‑proof container. Inert gas sealing is strongly recommended for long‑term storage to prevent NHS ester hydrolysis and preserve polymer reactive activity and structural integrity.
Handling: Strictly avoid moisture intrusion, high‑temperature environments and prolonged air exposure, as NHS groups are highly moisture‑sensitive and prone to deactivation. Avoid repeated freeze‑thaw cycles to maintain stable conjugation efficiency.
PLGA NHS Capped, MW 2K combines high amine‑specific NHS reactivity, excellent solubility and fast degradability, acting as a universal reactive biodegradable polymer for high‑efficiency bioconjugation, rapid‑release targeted drug delivery and short‑cycle biomaterial functional modification research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.