PLGA Maleimide Capped, MW 40K is a premium ultra-high-molecular-weight, maleimide-terminated reactive biodegradable PLGA copolymer, representing the highest stability grade in the PLGA-MAL series. Specially developed for ultra-long-term implantable biomedical systems, multi-year sustained drug delivery and high-rigidity durable biomaterial functionalization, this polymer features ultra-dense chain entanglement, extreme mechanical toughness and multi-year slow degradability. With fully tunable standard and custom lactide-glycolide ratios, it maintains stable maleimide reactive activity throughout ultra-long in vivo cycles for permanent thiol bioconjugation.
Basic Specifications
Alternative Name: PLGA-Maleimide, PLGA-MAL
Polymer Composition: Poly(D,L-lactide-co-glycolic acid)-Maleimide
Lactide Ratio: 50:50, 65:35, 75:25, 85:15, Custom synthesis
Molecular Weight: 40K, Custom
Appearance: White to off-white solid
Key Features and Benefits
Ultra-Stable Maleimide Terminal Reactivity: Possesses highly active and chemically robust terminal maleimide functional groups, enabling ultra-high-efficiency, site-specific covalent click conjugation with thiol (-SH) groups under mild physiological conditions. The formed thioether bond exhibits exceptional chemical inertness and anti-fatigue performance, resisting degradation and dissociation during multi-year in vivo circulation and polymer erosion, realizing permanent biomolecule functional modification.
Full Customizable PLGA Ratio System: Covers all mainstream industrial ratios including 50:50, 65:35, 75:25, 85:15 and supports full custom synthesis. Accurate ratio fine-tuning precisely balances polymer hydrophobicity, mechanical rigidity and multi-year degradation kinetics, fully meeting the strict formulation requirements of long-acting implantable devices and ultra-durable targeted delivery systems.
Top-Tier 40K Ultra-High MW Structural Performance: As the highest molecular weight specification in the PLGA-MAL series, 40K grade forms extremely compact polymer chain entanglement, delivering maximum mechanical strength, anti-deformation stability and structural durability. It features the slowest, most uniform degradation cycle among all maleimide-functionalized PLGA variants, completely eliminating particle collapse, structural fatigue and premature drug release for multi-year ultra-long-release systems.
Max Biocompatibility & Mild Long-Term Degradation: Adopts high-purity biocompatible PLGA backbone, achieving mild, traceable and uniform hydrolytic degradation into endogenous non-toxic lactic acid and glycolic acid. No local inflammation, tissue irritation or residual toxicity is generated during multi-year degradation, fully conforming to clinical implantable material standards and long-term translational medical research requirements.
Permanent Conjugation Stability: Adopts precise terminal single-point maleimide capping technology, ensuring uniform reactive group distribution and ultra-long-term activity retention. The covalent coupling system maintains stable functional activity throughout the entire polymer degradation cycle, effectively preventing ligand shedding, functional failure and targeting attenuation in ultra-long-cycle biomedical applications.
Applications
Multi-Year Permanent Thiol Bioconjugation: Ideal for ultra-stable covalent modification of high-value therapeutic antibodies, sustained-release proteins, long-acting polypeptide drugs and thiolated targeting ligands, supporting the preparation of permanently functionalized biomolecular probes and long-term biological recognition systems.
Multi-Year Ultra-Long Sustained Drug Delivery: Exclusively applicable for implantable long-acting drug delivery devices and multi-year controlled-release formulations, solving the cycle limitation of conventional low/medium/high MW PLGA materials, suitable for long-term chronic disease intervention and sustained treatment research.
Ultra-Durable Implantable Carrier Functionalization: Serves as a high-rigidity reactive modification matrix for long-term implantable nanoparticles, microspheres and scaffold carriers, stably fixing targeted ligands to achieve long-term in vivo retention and persistent targeted enrichment.
Long-Life Biomedical Material Construction: Widely used for functional crosslinking and surface modification of multi-year degradable hydrogels and implantable tissue engineering scaffolds, supporting the development of high-toughness, long-service-life intelligent biomedical materials and implantable devices.
Storage and Handling
Storage: Store at –20 °C in a fully sealed, dry, moisture-proof container. Inert gas sealing is mandatory for long-term inventory storage to completely retain maleimide reactive activity and ultra-rigid polymer structural integrity.
Handling: Strictly avoid moisture invasion, high-temperature exposure and prolonged air contact to prevent maleimide group hydrolysis and deactivation; prohibit repeated freeze-thaw cycles to ensure stable polymer mechanical properties and persistent reactivity.
PLGA Maleimide Capped, MW 40K is a top-grade ultra-high-rigidity reactive PLGA copolymer integrating multi-year degradability, permanent thiol-reactive activity and fully tunable ratios, professionally designed for multi-year bioconjugation, ultra-long-acting implantable drug delivery and high-durability advanced biomedical material research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.