PLGA Maleimide Capped, MW 20K is an ultra-high-molecular-weight, maleimide-terminated reactive biodegradable PLGA copolymer engineered for ultra-stable thiol bioconjugation, ultra-long-cycle nanoparticle functionalization, and multi-stage sustained targeted drug delivery research. Featuring tunable standard and custom lactide-glycolide ratios, this ultra-high-MW polymer delivers exceptional structural rigidity and extended slow degradation kinetics, perfectly suited for long-term in vivo biomedical applications and high-durability functional material modification.
Basic Specifications
Alternative Name: PLGA-Maleimide, PLGA-MAL
Polymer Composition: Poly(D,L-lactide-co-glycolic acid)-Maleimide
Lactide Ratio: 50:50, 65:35, 75:25, 85:15, Custom synthesis
Molecular Weight: 20K, Custom
Appearance: White to off-white solid
Key Features and Benefits
Reactive Maleimide Terminal Group: Equipped with highly active terminal maleimide functional groups, enabling specific, high-yield covalent click conjugation with thiol (-SH) groups under mild physiological conditions. The formed thioether bond features excellent chemical stability and ultra-low non-specific binding, maintaining stable biomolecule coupling throughout ultra-long in vivo degradation cycles for persistent functional modification.
Full Tunable PLGA Ratio Options: Covers mainstream 50:50, 65:35, 75:25, 85:15 lactide-glycolide ratios and full custom synthesis services. Precise ratio modulation accurately tailors polymer hydrophobicity, ultra-long degradation kinetics and mechanical toughness, fully adapting to ultra-long-cycle sustained-release formulations and high-rigidity biomaterial modification scenarios.
Premium 20K Ultra-High Molecular Weight Performance: Ultra-high 20K molecular weight forms extremely dense polymer chain entanglement, delivering industry-leading structural rigidity, anti-deformation performance and morphological stability compared to low, medium and conventional high-MW PLGA. It features uniform, ultra-slow degradation behavior, completely avoiding particle rupture, structural fatigue and premature drug leakage, ideal for multi-month long-cycle sustained-release carrier fabrication.
Excellent Biocompatibility & Biodegradability: Possesses superior physiological biocompatibility and biosafety, undergoing mild, uniform hydrolysis into non-toxic endogenous lactic acid and glycolic acid in vivo. No inflammatory stimulation, tissue irritation or toxic residue occurs, fully compliant with ultra-long-term in vivo implantation and translational biomedical research standards.
Ultra-Long Stable Conjugation Efficiency: Precision terminal maleimide capping guarantees persistent high reactive activity, enabling repeatable high-efficiency thiol click reactions. The robust covalent coupling structure effectively prevents ligand shedding and functional attenuation, retaining stable targeting and functional performance of modified carriers during ultra-long polymer degradation cycles.
Applications
Ultra-Long-Cycle Thiol-Specific Bioconjugation: Optimized for durable covalent modification of cysteine-rich antibodies, therapeutic proteins, peptides and thiolated targeting ligands, supporting long-term stable biomolecule assembly and persistent functional probe preparation.
Multi-Month Sustained Targeted Drug Delivery: Designed for manufacturing high-rigidity PLGA nanoparticles and microspheres with ultra-long degradation cycles, enabling multi-month uniform sustained drug release and stable in vivo targeted enrichment for chronic disease long-acting treatment formulation development.
Ultra-Stable Nanoparticle Surface Functionalization: Serves as a high-durability reactive polymer matrix for surface engineering of long-acting implantable carriers, stably immobilizing targeting groups to enhance in vivo circulation persistence and long-term targeted accumulation efficiency.
Long-Duration Biomaterial Functional Modification: Widely applied in functional crosslinking and modification of ultra-long degradable hydrogels and implantable tissue engineering scaffolds, supporting the construction of high-toughness, long-service-life reactive biomedical materials.
Storage and Handling
Storage: Store at –20 °C in a sealed, dry, moisture-proof container. Inert gas sealing is strongly recommended for long-term storage to fully protect maleimide reactive activity and polymer structural integrity.
Handling: Avoid moisture intrusion, high-temperature environments and prolonged air exposure to prevent maleimide hydrolysis and deactivation; strictly avoid repeated freeze-thaw cycles to maintain stable polymer reactivity and mechanical properties.
PLGA Maleimide Capped, MW 20K integrates ultra-high structural rigidity, ultra-long tunable degradability and persistent thiol-reactive activity, serving as a high-end reactive functional polymer for ultra-stable long-cycle bioconjugation, multi-month sustained targeted drug delivery and high-durability biodegradable material modification research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.