PLGA Maleimide Capped, MW 5K is a medium-molecular-weight, maleimide-terminated reactive biodegradable PLGA copolymer tailored for high-efficiency thiol-specific bioconjugation, universal nanoparticle functionalization, and medium-term sustained targeted drug delivery research. It supports diverse standard and custom lactide-glycolide ratios, balancing excellent solubility, moderate structural stability and steady degradation performance, making it a versatile reactive polymer for routine biomedical formulation and biomolecule modification.
Basic Specifications
Alternative Name: PLGA-Maleimide, PLGA-MAL
Polymer Composition: Poly(D,L-lactide-co-glycolic acid)-Maleimide
Lactide Ratio: 50:50, 65:35, 75:25, 85:15, Custom synthesis
Molecular Weight: 5K, Custom
Appearance: White to off-white solid
Key Features and Benefits
Reactive Maleimide Terminal Group: Active terminal maleimide groups enable highly specific, high-yield covalent conjugation with thiol (-SH) groups under mild physiological conditions. The stable thioether bond formed by thiol-maleimide click reaction features low side reactivity and non-reversible binding, ensuring reliable and long-term stable biomolecular modification.
Full Tunable PLGA Ratio Options: Covers mainstream 50:50, 65:35, 75:25, 85:15 lactide-glycolide ratios and full custom synthesis services. Precise ratio tuning flexibly adjusts polymer hydrophilicity, degradation cycle and particle morphology to fit various medium-term sustained-release and functional modification scenarios.
Balanced 5K Medium Molecular Weight Performance: Medium 5K molecular weight achieves an optimal balance of good organic solubility and enhanced structural rigidity compared to low-MW PLGA. It delivers uniform, moderate degradation speed, avoiding overly fast burst release and structural instability, perfectly suitable for standard medium-cycle sustained drug delivery and stable nanoparticle preparation.
Excellent Biocompatibility & Biodegradability: Features superior physiological biocompatibility and biosafety, gradually hydrolyzing into non-toxic lactic acid and glycolic acid in vivo. No inflammatory stimulation or toxic residue occurs, fully compliant with in vitro conjugation experiments and medium-term in vivo biomedical applications.
Stable Conjugation Efficiency: Uniform terminal maleimide capping maintains high and consistent reactive activity, ensuring repeatable high-efficiency bioconjugation. The covalent coupling structure effectively prevents ligand shedding, stabilizing the targeting and functional performance of modified drug carriers.
Applications
Universal Thiol-Specific Bioconjugation: Widely applied for covalent modification of cysteine-containing proteins, antibodies, peptides and thiolated targeted ligands, supporting stable functional biomolecule assembly and biomedical probe preparation.
Medium-Term Sustained Targeted Drug Delivery: Ideal for preparing structurally stable PLGA nanoparticles and microspheres, realizing uniform medium-cycle sustained drug release and active targeted delivery for conventional disease treatment and routine pharmaceutical research.
Stable Nanoparticle Surface Functionalization: Serves as a high-performance reactive matrix for surface engineering of biodegradable carriers, efficiently introducing targeting groups to enhance carrier specificity and in vivo enrichment stability.
Biomaterial Functional Modification: Used for functional crosslinking and modification of biodegradable hydrogels and tissue engineering scaffolds, supporting the development of stable reactive functional biomedical materials.
Storage and Handling
Storage: Store at –20 °C in a sealed, dry, moisture-proof container. Inert gas sealing is recommended for long-term storage to preserve maleimide reactive activity and polymer structural integrity.
Handling: Avoid moisture intrusion, high-temperature environment and prolonged air exposure to prevent maleimide hydrolysis and deactivation; avoid repeated freeze-thaw cycles.
PLGA Maleimide Capped, MW 5K balances moderate degradability, stable structural performance and high thiol-reactive activity with tunable multi-ratio formulation, acting as a versatile reactive functional polymer for universal bioconjugation, medium-term sustained targeted drug delivery and standard biodegradable material modification research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.