PLGA Maleimide Capped, MW 5K is a maleimide-functionalized poly(lactic-co-glycolic acid) with a molecular weight of approximately 5K. It combines a low-molecular-weight, biodegradable PLGA backbone with terminal maleimide functionality specifically for thiol-selective conjugation, bioconjugation, polymer functionalization, nanoparticle modification, surface modification, and biomaterial research.
Key Features and Benefits
- Maleimide-Capped PLGA: Combines biodegradable poly(lactic-co-glycolic acid) with terminal maleimide functionality for selective chemical conjugation.
- MW 5K: Provides a low molecular weight with good processability specifically for polymer functionalization, particle formulation, and conjugation research.
- Maleimide Functionality: The terminal maleimide group provides a reactive site specifically for selective coupling with compatible thiol-containing molecules under appropriate conditions.
- Thiol-Reactive Platform: Supports thiol-maleimide coupling to form stable covalent linkages with thiol-containing peptides, proteins, ligands, polymers, and other molecules.
- Biodegradable Copolymer: The PLGA backbone contains hydrolyzable ester linkages that specifically support gradual polymer degradation under appropriate conditions.
- Lactide-Glycolide Backbone: Combines lactic acid- and glycolic acid-derived units in a biodegradable polyester platform for polymer and drug-delivery research.
- Good Processability: The low molecular weight facilitates polymer dissolution, formulation, particle preparation, and chemical functionalization compared with higher-molecular-weight PLGA grades.
- Versatile Conjugation Platform: Terminal maleimide functionality enables functionalization with compatible thiol-containing biomolecules, ligands, polymers, and other functional compounds.
Applications
- Thiol-Maleimide Coupling: Enables selective conjugation with compatible thiol-containing molecules through maleimide chemistry.
- Bioconjugation: Supports attachment of thiol-containing peptides, proteins, ligands, and other compatible biomolecules.
- Polymer Functionalization: Supports preparation of functional PLGA derivatives and more complex polymer architectures.
- Nanoparticle Functionalization: Enables modification of PLGA nanoparticles and related polymeric delivery systems with thiol-containing functional molecules.
- Ligand Conjugation: Supports attachment of compatible thiol-containing targeting ligands and functional molecules.
- Surface Modification: Enables functionalization of PLGA-containing surfaces, coatings, and materials.
- Drug Delivery: Supports development of functional biodegradable polymer systems for drug-delivery and controlled-release research.
- Biomaterial Research: Supports development of functional biodegradable polymers, particles, coatings, composites, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions. Protect from moisture and excessive heat.
- Handling: Protect from moisture and prolonged exposure to conditions that may promote maleimide hydrolysis. Allow the material to equilibrate to room temperature before opening to minimize moisture condensation.
PLGA Maleimide Capped, MW 5K provides a low-molecular-weight biodegradable PLGA platform with terminal maleimide functionality and good processability for selective thiol conjugation and specifically supports bioconjugation, polymer functionalization, nanoparticle modification, ligand attachment, drug-delivery research, and functional biomaterial development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.