PLGA Maleimide Capped, MW 10K is a high-molecular-weight, maleimide-terminated reactive biodegradable PLGA copolymer designed for high-stability thiol bioconjugation, long-cycle nanoparticle functionalization, and prolonged sustained targeted drug delivery research. Supporting comprehensive standard and custom lactide-glycolide ratios, this high-MW polymer features enhanced structural rigidity and extended degradation cycle, delivering reliable reactive performance for long-term biomedical formulation and stable biomolecule modification scenarios.
Basic Specifications
Alternative Name: PLGA-Maleimide, PLGA-MAL
Polymer Composition: Poly(D,L-lactide-co-glycolic acid)-Maleimide
Lactide Ratio: 50:50, 65:35, 75:25, 85:15, Custom synthesis
Molecular Weight: 10K, Custom
Appearance: White to off-white solid
Key Features and Benefits
Reactive Maleimide Terminal Group: Functionalized with active terminal maleimide groups, enabling highly specific, high-yield covalent click conjugation with thiol (-SH) groups under mild physiological conditions. The formed thioether bond possesses excellent chemical stability and low non-specific reactivity, ensuring durable and reliable covalent modification of biomolecules for long-cycle experimental and in vivo applications.
Full Tunable PLGA Ratio Options: Covers mainstream 50:50, 65:35, 75:25, 85:15 lactide-glycolide ratios and full custom synthesis services. Precise ratio regulation flexibly modulates polymer hydrophilicity, degradation kinetics and particle mechanical properties, fully adapting to various long-term sustained-release and high-stability functional modification requirements.
Enhanced 10K High Molecular Weight Performance: High 10K molecular weight forms dense polymer chain entanglement, providing significantly improved structural rigidity, morphological stability and anti-deformation capability compared to medium and low-MW PLGA. It features uniform, prolonged degradation behavior, effectively avoiding particle rupture, structural failure and premature drug leakage, perfectly suited for long-cycle stable sustained-release carrier preparation.
Excellent Biocompatibility & Biodegradability: Exhibits superior physiological compatibility and biosafety, gradually and uniformly hydrolyzing into endogenous non-toxic lactic acid and glycolic acid in physiological environments. No inflammatory stimulation or toxic residue is generated, fully compliant with long-term in vivo tracing, sustained drug delivery and advanced biomedical research standards.
Long-Term Stable Conjugation Efficiency: Precise terminal maleimide capping ensures consistent high reactive activity, delivering repeatable high-efficiency thiol click reactions. The stable covalent coupling structure effectively prevents ligand shedding and functional attenuation, maintaining persistent targeting and functional stability of modified drug delivery systems throughout long degradation cycles.
Applications
Long-Cycle Thiol-Specific Bioconjugation: Ideal for stable covalent modification of cysteine-rich proteins, antibodies, therapeutic peptides and thiolated targeting ligands, supporting durable biomolecule assembly and long-term functional probe preparation.
Prolonged Sustained Targeted Drug Delivery: Optimized for fabricating high-stability PLGA nanoparticles and microspheres, enabling long-cycle uniform sustained drug release and stable in vivo targeted enrichment for chronic disease treatment and long-acting formulation development.
High-Stability Nanoparticle Surface Functionalization: Acts as a robust reactive polymer matrix for surface engineering of long-acting biodegradable carriers, stably immobilizing targeting groups to enhance in vivo circulation stability and targeted accumulation efficiency.
Durable Biomaterial Functional Modification: Widely used for functional crosslinking and modification of long-term degradable hydrogels and tissue engineering scaffolds, supporting the construction of high-durability reactive functional biomedical materials.
Storage and Handling
Storage: Store at –20 °C in a sealed, dry, moisture-proof container. Inert gas sealing is strongly recommended for long-term storage to fully preserve maleimide reactive activity and polymer structural integrity.
Handling: Avoid moisture intrusion, high-temperature environments and prolonged air exposure to prevent maleimide group hydrolysis and deactivation; strictly avoid repeated freeze-thaw cycles to ensure stable polymer performance.
PLGA Maleimide Capped, MW 10K integrates high structural stability, long-cycle tunable degradability and persistent thiol-reactive activity, serving as a high-performance reactive functional polymer for long-term stable bioconjugation, prolonged sustained targeted drug delivery and durable biodegradable material modification research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.