PLGA Maleimide Capped, MW 2K is a low-molecular-weight, maleimide-terminated reactive biodegradable PLGA copolymer designed for efficient thiol-specific bioconjugation, surface functional modification, and rapid-release targeted drug delivery research. Supporting multiple standard and custom lactide-glycolide ratios, this low-MW polymer features excellent solubility and fast, uniform degradation, serving as an ideal reactive building block for covalent biomolecule coupling and advanced nanoparticle formulation.
Basic Specifications
Alternative Name: PLGA-Maleimide, PLGA-MAL
Polymer Composition: Poly(D,L-lactide-co-glycolic acid)-Maleimide
Lactide Ratio: 50:50, 65:35, 75:25, 85:15, Custom synthesis
Molecular Weight: 2K, Custom
Appearance: White to off-white solid
Key Features and Benefits
Reactive Maleimide Terminal Group: Terminal maleimide functional group enables highly specific, efficient covalent conjugation with thiol (-SH) groups under mild physiological conditions. The thiol-maleimide click reaction features high yield, low side reactivity and stable coupling bonds, supporting reliable and irreversible biomolecular modification.
Full Tunable PLGA Ratio Options: Covers mainstream 50:50, 65:35, 75:25, 85:15 lactide-glycolide ratios and full custom synthesis services. Precise ratio adjustment flexibly regulates polymer hydrophilicity, degradation speed and particle morphology to match diverse rapid and medium-release formulation scenarios.
Low 2K Molecular Weight Advantage: Low molecular weight endows the polymer with excellent organic solubility and fast, homogeneous hydrolytic degradation. It ensures rapid carrier erosion and complete drug release, perfectly suited for short-cycle drug delivery systems and fast functional surface modification.
Excellent Biocompatibility & Biodegradability: Possesses superior biosafety and physiological compatibility, fully hydrolyzing into non-toxic lactic acid and glycolic acid without inflammatory irritation or toxic residue, suitable for in vitro conjugation experiments and short-term in vivo biomedical applications.
High Conjugation Efficiency & Stability: Uniform terminal maleimide capping ensures high reactive group activity and consistent coupling efficiency. The formed thioether bond is chemically stable, preventing biomolecule shedding and ensuring long-term functional stability of modified materials.
Applications
Thiol-Specific Bioconjugation: Widely used for covalent modification of cysteine-containing peptides, proteins, antibodies and thiolated ligands via high-efficiency thiol-maleimide click chemistry.
Rapid-Release Targeted Drug Delivery: Ideal for preparing fast-degrading PLGA nanoparticles and microspheres, enabling short-cycle controlled drug release and active targeted delivery for acute disease treatment and rapid therapeutic intervention.
Nanoparticle Surface Functionalization: Serves as a reactive polymer matrix for surface engineering of biodegradable carriers, efficiently introducing targeted ligands and biological probes to enhance carrier targeting specificity.
Biomedical Material Crosslinking & Modification: Applied in functional modification of biodegradable scaffolds and hydrogels, supporting the construction of custom reactive biomaterials and functional biomedical interfaces.
Storage and Handling
Storage: Store at –20 °C in a sealed, dry, moisture-proof container. Inert gas sealing is recommended for long-term storage to protect maleimide reactive activity and polymer stability.
Handling: Avoid moisture, high temperature and prolonged exposure to air to prevent maleimide group hydrolysis and deactivation; avoid repeated freeze-thaw cycles.
PLGA Maleimide Capped, MW 2K integrates high thiol-reactive activity, excellent solubility and fast degradability with tunable multi-ratio formulation, serving as a universal reactive functional polymer for efficient bioconjugation, rapid-release targeted drug delivery and biodegradable material modification research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.