PLGA Biotin Capped, MW 10K is a high-molecular-weight biodegradable PLGA copolymer with terminal biotin functionalization, configurable with multiple lactide-glycolide ratios including 50:50, 75:25, 85:15 and customized formulations. This high-molecular polymer delivers superior structural stability and prolonged degradation performance, ideal for long-term targeted drug delivery, stable bioconjugation, robust particle fabrication, and advanced biomedical biomaterial research.
Key Features and Benefits
Biotin Capped: Features active terminal biotin functional groups, enabling ultra-high-affinity, specific binding with avidin and streptavidin, supporting reliable and repeatable biomolecular conjugation and surface functionalization.
Lactide Ratio Available: Supports standard ratios of 50:50, 75:25, 85:15 and fully custom lactide-glycolide proportions, allowing precise adjustment of degradation cycle, hydrophobicity and mechanical properties to fit diverse experimental and formulation needs.
MW 10K: High molecular weight provides excellent structural rigidity, enhanced polymer chain entanglement, and significantly extended degradation time compared to low/medium MW PLGA. It ensures superior particle morphology stability and long-term sustained release effects without compromising organic solubility and processing performance.
Biocompatible & Biodegradable: Fully biocompatible and non-toxic in physiological environments, gradually hydrolyzing into natural lactic acid and glycolic acid, ensuring high biosafety for in vitro and in vivo biomedical applications.
Highly Versatile Functional Polymer: Combines biotin targeting capability and high-polymer structural advantages, suitable for manufacturing stable nanoparticles, durable microspheres, functional biodegradable coatings, and long-acting polymer matrix materials.
Applications
Long-Term Targeted Drug Delivery: Optimized for long-cycle sustained-release drug formulations and active-targeted delivery systems, solving short release duration limitations of low-molecular PLGA materials.
Stable Biotin-Avidin Bioconjugation: Reliable terminal biotin activity enables stable coupling with streptavidin-modified antibodies, fluorescent probes, proteins and bio-ligands for accurate biomedical targeting research.
High-Stability Polymer Modification: Acts as a high-performance biotin-functionalized PLGA precursor for advanced polymer derivatization and stable biomaterial functional modification.
Robust Polymeric Particle Fabrication: Ideal for preparing structurally stable PLGA nanoparticles and microspheres, effectively preventing particle deformation and premature drug leakage during storage and application.
Durable Biomedical Biomaterials: Widely applied in long-acting biodegradable scaffolds, functional surface coatings, implantable biomaterials and sustained-release diagnostic & therapeutic carriers.
Storage and Handling
Storage: Store at –20 °C in a sealed, dry, moisture-proof container; inert atmosphere storage is recommended for long-term preservation to maintain polymer structure and biotin activity.
Handling: Avoid moisture exposure, repeated freeze-thaw cycles and overheating conditions to prevent polymer hydrolysis, structural damage and deactivation of terminal biotin functional groups.
PLGA Biotin Capped, MW 10K integrates high molecular weight structural stability, tunable multi-ratio degradability, and specific biotin targeting function, uniquely engineered for long-term sustained drug delivery, stable high-affinity bioconjugation, and durable functional biomaterial development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.