Alkyne-Polysarcosine-200 is an alkyne-functionalized hydrophilic polypeptoid with approximately 200 sarcosine repeat units. It combines an extended polysarcosine chain with terminal alkyne functionality specifically for click chemistry, bioconjugation, surface modification, and biomaterial research.
Key Features and Benefits
- Alkyne-Functionalized Polysarcosine: Combines a hydrophilic polysarcosine backbone with a terminal alkyne group for selective functionalization.
- 200 Repeat Units: Provides approximately 200 sarcosine units for applications requiring an extended hydrophilic polymer chain.
- Alkyne Functionality: The terminal alkyne provides a reactive site specifically for coupling with compatible azide-containing molecules.
- Click Chemistry Platform: Supports CuAAC reactions between the terminal alkyne and azide-functionalized molecules.
- High Hydrophilicity: The polysarcosine backbone provides strong hydrophilic character and supports aqueous compatibility.
- Low Nonspecific Interactions: Polysarcosine can help reduce nonspecific protein interactions in suitable polymer and surface systems.
- PEG Alternative: Provides a non-PEG hydrophilic platform specifically for functional polymer design, conjugation, and surface engineering.
- Versatile Functionalization: Combines click-reactive functionality with a hydrophilic polymer chain for advanced material development.
Applications
- Click Chemistry: Supports CuAAC coupling with compatible azide-functionalized molecules.
- Bioconjugation: Enables attachment of compatible azide-functionalized peptides, proteins, ligands, and other molecules.
- Polymer Functionalization: Supports incorporation into block copolymers, polymer conjugates, and other functional architectures.
- Nanoparticle Functionalization: Enables click-mediated modification of compatible nanoparticles and polymeric systems.
- Surface Modification: Supports attachment of polysarcosine chains to suitably azide-functionalized surfaces.
- Drug Delivery: Supports development of functional hydrophilic polymer systems for drug-delivery research.
- Low-Fouling Materials: Supports development of hydrophilic materials designed to reduce nonspecific interactions.
- Biomaterial Research: Supports development of polymer conjugates, functional surfaces, nanoparticles, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to reach room temperature before opening to minimize condensation.
Alkyne Polysarcosine 200 combines an extended hydrophilic polysarcosine chain with terminal alkyne functionality and specifically supports click chemistry, bioconjugation, surface modification, nanoparticle functionalization, and biomaterial development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
