DBCO-NH-PEG2-amine
This product is a heterobifunctional linker containing a dibenzocyclooctyne (DBCO) group, a short PEG2 spacer, and a terminal primary amine. The DBCO enables rapid, copper-free SPAAC click chemistry with azides, while the amine couples efficiently with carboxyls or activated esters. The PEG2 chain offers compact spacing with improved solubility, making this reagent especially ideal for dual-functional bioconjugation in crowded systems.
Key Features and Benefits
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DBCO Group: Supports ultrafast, copper-free SPAAC click chemistry with azides.
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Primary Amine: Couples readily with carboxyl or NHS esters for amide formation.
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PEG2 Spacer: Provides hydrophilicity with minimal added length.
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Dual Reactivity: Combines orthogonal click chemistry and amine coupling.
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High Purity: Manufactured to ≥95% purity for reproducibility.
Applications
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Bioconjugation: Links azide-modified and carboxyl-containing biomolecules.
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Protein and Antibody Labeling: Enables compact site-specific modifications.
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Probe Development: Builds dual-functional probes for imaging and diagnostics.
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Drug Delivery: Serves as a modular linker for PEGylated therapeutics.
Storage and Handling
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Storage: Store at –20 °C in a sealed, moisture- and light-protected container.
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Handling: Prepare fresh solutions before use; avoid repeated freeze–thaw cycles.
This product combines copper-free click reactivity with amine functionality in a short PEG design, making it especially well-suited for efficient bioconjugation and probe development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
