DBCO-Amine (Dibenzocyclooctyne Amine)
CAS: 1255942-06-3
Description:
DBCO-Amine, or Dibenzocyclooctyne Amine, is a functionalized DBCO derivative designed for copper-free click chemistry. It contains a reactive amine group, allowing for easy conjugation to carboxyl-containing molecules. The DBCO structure enables rapid and efficient click reactions with azide groups under mild conditions, often used in bioconjugation.
Key Features:
- Copper-Free Click Chemistry: Facilitates bioorthogonal reactions without the need for toxic copper catalysts, making it ideal for live-cell applications.
- Amine Functional Group: Enables straightforward conjugation to carboxylated molecules for versatile labeling and linking.
- Applications: Commonly used in labeling proteins, antibodies, and other biomolecules in bioconjugation and drug development.
Applications:
- Bioconjugation: Widely used for linking biomolecules, especially in creating antibody-drug conjugates (ADCs).
- Molecular Imaging & Tracking: Suitable for live-cell labeling in fluorescence imaging and tracking studies, given its bioorthogonal reactivity.
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