DMG-PEG-Mal 1000

Key Properties

• A heterobifunctional PEGylated lipid consisting of a hydrophobic DMG (dimyristoyl glycerol) anchor, a hydrophilic PEG 1000 spacer, and a reactive maleimide (Mal) end group.
• Amphiphilic and neutral at physiological pH, enabling stable insertion into lipid bilayers of LNPs and liposomes.
• The maleimide group reacts specifically with thiol groups (-SH) under mild neutral conditions to form stable covalent thioether bonds.
• Provides both PEG-derived stealth effect and conjugation capability for targeted modification.
• Good biocompatibility, low toxicity, and reduced non-specific protein adsorption.
• Soluble in chloroform, methanol, ethanol, and DMSO; moderately dispersible in aqueous buffers.
• Usually a white to off-white waxy solid.
• Storage: −20 °C, desiccated, protected from light and moisture to avoid maleimide hydrolysis.

Applications

• Used as a reactive PEG lipid for targeted functionalization of lipid nanoparticles (LNPs), liposomes, and micelles.
• Enables conjugation with thiol-containing ligands, peptides, antibodies, aptamers, and targeting molecules.
• Applied in mRNA, siRNA, DNA, and protein delivery systems to enhance targeting specificity.
• Improves colloidal stability and prolongs in vivo circulation time of nanocarriers.
• Used in the development of targeted drug delivery systems, theranostic platforms, and vaccine delivery vehicles.
• Serves as a versatile building block for surface engineering of lipid-based nanomedicines.