DSPE-Polysarcosine10 (DSPE-pSar10)

Key Properties

• An amphiphilic lipid-polypeptoid conjugate consisting of the phospholipid DSPE (1,2-distearoyl-sn-glycero-3-phosphoethanolamine) covalently linked to a short polysarcosine (pSar) chain with 10 repeating sarcosine (N-methylglycine) units.
• Combines the lipophilic bilayer-anchoring property of DSPE with the hydrophilic, stealth-like characteristics of polysarcosine.
• Exhibits excellent water solubility, low non-specific protein adsorption, and minimal immunogenicity, serving as a promising alternative to PEGylated lipids.
• Biodegradable, biocompatible, and low in cytotoxicity.
• Soluble in organic solvents (chloroform, methanol, DMSO) and dispersible in aqueous media to form stable self-assembled structures.
• Typically supplied as a white to off-white solid or powder.
• Storage: −20 °C, desiccated and protected from light/oxidation.

Applications

• Used as a stealth helper lipid in liposomes, lipid nanoparticles (LNPs), and micellar formulations for drug and nucleic acid delivery.
• Reduces immune recognition and extends blood circulation half-life of nanocarriers by minimizing opsonizationWiley Onli….
• Enhances colloidal stability and membrane integrity of lipid-based delivery systems.
• Applied in mRNA/vaccine delivery, gene therapy, and targeted small-molecule drug carriers.
• Serves as a PEG alternative to mitigate accelerated blood clearance (ABC) and complement activation issues associated with PEGylated lipidsWiley Onli….
• Used in surface modification of biomaterials and liposomal systems for improved biocompatibilityWiley Onli…