DSPE
Full name: 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine
CAS No.: 1069-79-0
Key Properties
- A synthetic phospholipid with two saturated stearic acid (C18:0) acyl chains and a phosphoethanolamine head group.
- High hydrophobicity and strong bilayer-forming stability, making it ideal for constructing liposomes and lipid nanoparticles.
- Contains a reactive primary amine (-NH₂) group on the head, enabling conjugation with various functional molecules.
- Biocompatible and low in toxicity, widely used in biological and pharmaceutical formulations.
- Practically insoluble in water but soluble in organic solvents such as chloroform, methanol, and ethanol.
- Usually appears as a white to off-white powder or waxy solid.
Applications
- Major component of liposomes, lipid nanoparticles (LNPs), and micelles for drug delivery.
- Used as a base lipid in vaccine delivery systems, especially PEGylated lipid formulations.
- Surface modification of nanoparticles, liposomes, and biomaterials via amine coupling reactions.
- Preparation of PEGylated lipids (e.g., DSPE-PEG) to prolong blood circulation time and reduce immune recognition.
- Stabilizer for emulsions, nanoparticle suspensions, and membrane models.
- Supportive component in gene delivery systems for DNA, mRNA, and siRNA transfection.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
