DBCO-C3-Amine
CAS: 1386999-75-2
Description:
DBCO-C3-Amine is a bifunctional linker for copper-free click chemistry (SPAAC), widely employed in bioconjugation, antibody-drug conjugate (ADC) development, live-cell imaging, and targeted drug delivery.
Key Features of DBCO-C3-Amine
- Copper-Free Click Chemistry: Enables rapid, bioorthogonal SPAAC reactions with azide-tagged molecules without toxic copper catalysts, ensuring excellent biocompatibility for live-cell and in vivo applications.
- C3 Alkyl Spacer Arm: The flexible three-carbon linker reduces steric hindrance, improves conjugation efficiency, and enhances structural stability compared with conventional DBCO-Amine.
- Reactive Amine Group: Provides a highly active amine terminus for stable amide bond formation with carboxyl-containing molecules, NHS esters, and other activated substrates.
- High Specificity & Stability: Reacts selectively with azides under mild aqueous conditions, with low non-specific binding and strong stability in physiological environments.
- Broad Biocompatibility: Minimizes damage to biomolecules and cells, making it ideal for protein labeling, antibody modification, and sensitive pharmaceutical research.
Applications:
- Bioconjugation: Widely used for site-specific modification of proteins, antibodies, peptides and other biomolecules in the preparation of antibody-drug conjugates (ADCs).
- Live-Cell Imaging & Tracking: Suitable for non-invasive fluorescence labeling and real-time tracking of biological targets due to its copper-free, low-toxicity reaction profile.
- Drug Delivery Systems: Applied in the construction of targeted delivery platforms, including nanoparticle functionalization and probe development for precision medicine.
- Biomedical Research: Used in bioorthogonal chemistry, diagnostic probe design, and the development of novel biotherapeutic materials.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
