Methyltetrazine-PEG8-Maleimide is a heterobifunctional linker featuring tetrazine for bioorthogonal IEDDA reactions and maleimide for thiol-specific conjugation, separated by a hydrophilic PEG8 spacer for enhanced solubility and reduced steric hindrance.
Key Features
- Methyltetrazine Group
Enables rapid and selective bioorthogonal reactions with strained alkenes (e.g., trans-cyclooctene). - Maleimide Group
Reacts specifically with thiol groups in proteins, peptides, and other biomolecules. - PEG8 Spacer
Provides excellent solubility in aqueous environments and flexibility for efficient conjugation.
Applications
- Bioconjugation
Ideal for site-specific labeling of biomolecules with dual functionality. - Drug Delivery Systems
Enables the development of targeted and cleavable therapeutic conjugates. - Molecular Probes
Facilitates the creation of functional imaging agents. - Material Functionalization
Useful for modifying surfaces, nanoparticles, and hydrogels.
Short Description
This product is a bifunctional linker with tetrazine for IEDDA reactions and maleimide for thiol conjugation, featuring a PEG8 spacer for solubility. Ideal for bioconjugation and targeted drug delivery.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
