Lys(MMT)-PAB-oxydiacetamide-PEG8-N3 (CAS: 1224601-12-0) is a bifunctional PEG-based linker used in the synthesis of antibody-drug conjugates (ADCs) and bioconjugation. It features a protected lysine residue (MMT group), a PAB spacer, an oxydiacetamide linker, and an azide group, connected by an eight-unit PEG chain for improved solubility and flexibility.
Key Features:
- Dual Reactivity: The azide group supports click chemistry reactions, while the MMT-protected lysine allows selective deprotection for further conjugation.
- Enhanced Solubility: The PEG8 spacer improves water solubility and reduces aggregation.
- Flexible Linker: The PEG chain increases molecular flexibility, reducing steric hindrance in bioconjugates.
ys(MMT)-PAB-oxydiacetamide-PEG8-N3 Applications:
- Antibody-Drug Conjugates (ADCs): Links cytotoxic drugs to antibodies for targeted cancer therapies.
- Bioconjugation: Connects peptides, proteins, and other biomolecules for research and therapeutic use.
- Click Chemistry: The azide group enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC).
Handling and Storage:
- Storage: Store in a cool, dry place, protected from light and moisture.
- Precautions: Use protective equipment and handle under inert atmosphere if required.
This versatile linker supports the development of advanced therapeutic agents and research tools through reliable bioconjugation and drug delivery technologies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
