DBCO-PEG₂₄-Maleimide (CAS: 2924872-84-2)
DBCO-PEG₂₄-Maleimide is a versatile bioconjugation reagent designed for precise and efficient linking of biomolecules. It features a dibenzocyclooctyne (DBCO) group for copper-free click chemistry and a maleimide group for thiol-specific conjugation.
Key Features:
- Dual Functional Groups:
- Maleimide Group: Reacts selectively with thiol groups (e.g., cysteine residues), forming stable thioether bonds.
- DBCO Group: Facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules for copper-free click reactions.
- Extended PEG Spacer:
- Contains 24 ethylene glycol units, enhancing water solubility and flexibility.
- Reduces steric hindrance, improving conjugation efficiency and biocompatibility.
Applications:
- Protein and Peptide Labeling:
- Links functional groups, fluorescent dyes, or biomolecules to thiol-containing proteins and peptides.
- Antibody-Drug Conjugates (ADCs):
- Attaches cytotoxic drugs to antibodies for targeted therapy, enhancing specificity and reducing side effects.
- Surface Functionalization:
- Modifies surfaces such as nanoparticles or biosensors, improving diagnostic sensitivity and specificity.
- Molecular Crosslinking:
- Stabilizes protein complexes and enables the study of molecular interactions.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
