Exatecan Mesylate (CAS 169869-90-3), also known as DX-8951f, is a water-soluble camptothecin derivative that inhibits DNA topoisomerase I. It demonstrates potent antitumor activity and is widely used in cancer research and drug development, including as a payload in antibody-drug conjugates (ADCs).
Key Features:
- Molecular Formula: C₂₅H₂₆FN₃O₇S
- Molecular Weight: 531.55 g/mol
- Mechanism: Inhibits DNA topoisomerase I, inducing DNA damage.
- Solubility: Soluble in DMSO and water.
Applications:
- Cancer Research: Studies drug efficacy, resistance, and mechanisms of action.
- Drug Development: Used in ADCs and chemotherapeutic design.
- Pharmacological Studies: Evaluates pharmacokinetics and combination therapies.
Exatecan Mesylate is a critical tool for advancing targeted cancer therapies and understanding topoisomerase I inhibitors.
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