Bis-PEG10-t-butyl ester is a versatile linear bifunctional PEGylation reagent, featuring two t-butyl ester-protected carboxylic acid groups at each end of a 10-unit polyethylene glycol (PEG) spacer. This hydrophilic polymer imparts biocompatibility, reduces immunogenicity, and enhances solubility of conjugated biomolecules, making it a vital tool in pharmaceutical research.
Introduction to the application:
In pharmaceutical research and development, Bis-PEG10-t-butyl ester has established itself as a crucial PEGylation agent, offering targeted drug delivery and prolonged circulation time. This reagent is employed for conjugation to peptides, proteins, and small molecules, optimizing their pharmacokinetic and pharmacodynamic properties. The t-butyl ester protecting groups ensure efficient and controlled conjugation, contributing to the development of effective and safer therapeutic agents.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
