Mal-Val-Ala-PAB CAS:2279940-93-9 is a small molecule linker that is commonly used in bioconjugation and drug delivery applications. It consists of several functional groups, including a maleimide group (Mal), a valine-alanine dipeptide (Val-Ala), and a p-aminobenzyloxycarbonyl (PAB) protecting group.
The maleimide group in Mal-Val-Ala-PAB is highly reactive with sulfhydryl groups on proteins and peptides, allowing it to form stable thioether linkages between the linker and the target molecule. The Val-Ala dipeptide provides a spacer arm that can help to minimize steric hindrance and improve the accessibility of the maleimide group to the target molecule. The PAB protecting group can be removed under mild conditions to reveal an amino group, which can be used for further conjugation or drug loading.
Mal-Val-Ala-PAB is a versatile linker that can be used to conjugate proteins, peptides, and small molecules with high efficiency and specificity. Its unique combination of functional groups makes it a valuable tool in drug discovery and development, and an essential component of modern pharmaceutical research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
