Methyltetrazine-PEG24-acid
This product is a heterobifunctional linker featuring a methyltetrazine group for ultrafast tetrazine ligation and a terminal carboxylic acid for amide coupling. The long PEG24 spacer imparts excellent solubility, flexibility, and extended spacing, making it especially ideal for ADC development, probe design, and drug delivery applications.
Key Features and Benefits:
-
Methyltetrazine Group: Supports rapid, copper-free IEDDA click chemistry with TCO.
-
Carboxylic Acid: Couples efficiently with amines under mild conditions.
-
PEG24 Spacer: Provides long-chain solubility, hydrophilicity, and steric accessibility.
-
Dual Reactivity: Combines bioorthogonal and amine-targeted chemistries.
-
High Purity: Ensures reproducibility in advanced workflows.
Applications:
-
ADC Development: Provides cleavable, PEGylated linkers for targeted therapeutics.
-
Probe Development: Builds tetrazine-modified imaging and diagnostic probes.
-
Bioconjugation: Links biomolecules through orthogonal chemistry.
-
Drug Delivery: Supports multifunctional conjugates with enhanced solubility.
Storage and Handling:
-
Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
-
Handling: Use anhydrous solvents (e.g., DMF, DMSO); protect from prolonged light exposure.
This product combines bioorthogonal tetrazine ligation with amine-coupling acid chemistry in a PEG24 scaffold, specifically offering extended flexibility and solubility for advanced conjugation workflows.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
