Topotecan Hydrochloride CAS:119413-54-6 is a semisynthetic camptothecin derivative characterized by a unique lactone E-ring functional group. This critical moiety imparts the compound’s potent inhibitory activity against topoisomerase I, an essential enzyme involved in DNA replication and repair processes.
Introduction to the application:
In pharmaceutical research and development, Topotecan Hydrochloride has emerged as a valuable chemotherapeutic agent. Its remarkable topoisomerase I inhibition properties have led to its successful application in treating various malignancies, including ovarian cancer, small cell lung cancer, and cervical cancer. The compound has been extensively studied for its potential in overcoming drug resistance and improving the efficacy of existing cancer therapies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.