THPTA (trihydroxypropyltriazolylmethylamine) CAS 760952-88-3 is a water-soluble, highly potent copper-catalyzed azide-alkyne cycloaddition (CuAAC) ligand for copper-catalyzed alkyne-azide Click Chemistry (CuAAC). In addition to greatly increasing the rate of CuAAC, THPTA minimizes interference with the physiological state of the probed cell or organism and enables efficient bioconjugation by further reducing the Cu loading in the catalyst formulation while suppressing cytotoxicity . Water-soluble THPTA ligands further simplify click chemistry by allowing the entire reaction to proceed in water.
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