THP-PEG8-Tos
This product is a heterobifunctional PEG linker featuring a tetrahydropyranyl (THP) protecting group and a tosyl (p-toluenesulfonyl) leaving group. The PEG8 spacer provides hydrophilicity and extended flexibility, making it especially useful for stepwise synthesis, bioconjugation, and advanced material design.
Key Features and Benefits:
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THP Group: Provides acid-labile protection for controlled deprotection.
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Tosyl Group: Serves as an efficient leaving group for substitution reactions.
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PEG8 Spacer: Enhances solubility, flexibility, and steric accessibility.
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Orthogonal Reactivity: Supports stepwise and multifunctional synthesis.
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High Purity: Ensures reproducibility in sensitive workflows.
Applications:
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Bioconjugation: Introduces orthogonal reactive handles to biomolecules.
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Drug Delivery: Provides PEGylated scaffolds with controlled release options.
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Probe Development: Builds protected intermediates for diagnostics and imaging.
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Synthetic Chemistry: Useful in linker and polymer synthesis.
Storage and Handling:
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Storage: Store at –20 °C in a sealed, moisture- and light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid premature THP cleavage.
This product integrates a THP-protected hydroxyl and a tosyl leaving group in a PEG8 scaffold, specifically offering solubility, spacing, and orthogonal control for advanced conjugation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
