Thalidomide-O-amido-PEG4-azide
This product is a heterobifunctional linker with a thalidomide moiety for cereblon (CRBN) recruitment and an azide group for click chemistry. The PEG4 spacer improves solubility, flexibility, and spacing, making it specifically used in PROTAC design, drug delivery, and targeted bioconjugation.
Key Features and Benefits:
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Thalidomide Moiety: Recruits CRBN E3 ligase for targeted protein degradation.
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Azide Group: Supports CuAAC and SPAAC click chemistry with alkynes.
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PEG4 Spacer: Adds solubility, flexibility, and steric accessibility.
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Dual Reactivity: Combines ligase binding with orthogonal conjugation.
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High Purity: Ensures reproducibility in drug discovery workflows.
Applications:
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PROTAC Development: Core linker for degrader molecule design.
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Drug Delivery: PEGylated scaffold improves solubility and pharmacokinetics.
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Bioconjugation: Enables dual-functional assembly strategies.
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Probe Development: Scaffold for CRBN-targeted chemical biology probes.
Storage and Handling:
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Storage: Store at –20 °C, sealed and protected from moisture and light.
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Handling: Use anhydrous solvents (e.g., DMSO, DMF) to preserve azide stability.
This product integrates CRBN recruitment with click chemistry functionality, specifically making it a critical building block for PROTACs and targeted therapeutics.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
