Tetrazine-PEG4-SS-NHS is a multifunctional reagent combining a tetrazine group for bioorthogonal IEDDA reactions, a redox-sensitive disulfide bond for controlled cleavability, and an NHS ester for efficient coupling to primary amines. The PEG4 spacer enhances solubility, minimizes steric hindrance, and ensures compatibility in biological and chemical systems.
Features
- Tetrazine Group: Enables fast and selective bioorthogonal conjugation with strained alkenes.
- Disulfide Bond: Provides redox-sensitive cleavability for controlled release.
- NHS Ester: Reacts efficiently with primary amines for stable covalent coupling.
- PEG4 Spacer: Enhances solubility and reduces steric interference.
- High Purity: ≥95% for reproducible and reliable results.
- Biocompatibility: Ideal for use in sensitive biological environments.
Applications
- Bioconjugation: Efficient modification of biomolecules through tetrazine and NHS chemistry.
- Drug Delivery: Design of redox-cleavable therapeutic systems.
- Imaging: Development of fluorescent or radiolabeled probes.
- Diagnostics: Functionalization for biosensors and assays.
- Chemical Biology: Studies in live cells or complex biological systems.
- Material Science: Functionalization of hydrogels and polymers for advanced applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
