Tetrazine-NHS ester CAS:1616668-55-3 is a versatile bioconjugation reagent, featuring a tetrazine moiety and N-hydroxysuccinimide (NHS) ester group. The tetrazine functionality participates in rapid, selective, and bioorthogonal inverse electron-demand Diels-Alder (IEDDA) reactions, while the NHS ester enables efficient amine-reactive coupling. This unique combination facilitates seamless conjugation with biomolecules, such as proteins, peptides, and nucleic acids.
In pharmaceutical research and development, Tetrazine-NHS ester plays a crucial role in enabling innovative strategies for drug delivery, bioimaging, and targeted therapeutics. Through rapid IEDDA reactions with trans-cyclooctene (TCO)-tagged molecules, Tetrazine-NHS ester allows for site-specific modification, enhancing the precision and efficacy of drug candidates. Additionally, its application in constructing fluorescent probes, radiolabeled tracers, and targeted nanoparticles contributes significantly to advancing our understanding of disease mechanisms and treatment modalities.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
