TCO-triethoxysilane (CAS: 2714298-10-7)
TCO-triethoxysilane combines a trans-cyclooctene (TCO) group with a triethoxysilane moiety, making it highly effective for surface modification and bioconjugation. The triethoxysilane group covalently bonds to hydroxyl-containing surfaces, such as glass and metal oxides, through silanization. At the same time, the TCO group enables rapid and selective bioorthogonal reactions with tetrazine-containing compounds. This dual functionality supports applications in material science, chemical biology, and advanced biomedical research.
Key Features:
- Reactive Groups:
- Triethoxysilane: Bonds to hydroxyl-rich surfaces, forming durable siloxane linkages that enable robust surface modification.
- Trans-Cyclooctene (TCO): Engages in fast, selective inverse electron-demand Diels-Alder (IEDDA) reactions with tetrazines, facilitating precise molecular conjugation.
- Molecular Properties:
- Molecular Formula: C₁₈H₃₅NO₅Si
- Molecular Weight: 373.56 g/mol
Applications:
- Surface Functionalization:
- Modifies glass, silicon, and metal oxide surfaces by introducing reactive TCO groups for further bioconjugation.
- Bioconjugation:
- Links biomolecules using tetrazine-TCO click chemistry, enabling the creation of targeted imaging agents, diagnostics, and therapeutics.
Handling and Storage:
- Storage Recommendations:
- Keep at -20°C in a cool, dry environment, away from light and moisture, to preserve stability.
Overall, TCO-triethoxysilane offers a powerful combination of surface-reactive and bioorthogonal properties. Its dual functionality significantly supports cutting-edge applications in surface modification, molecular tagging, and biomedical research, making it an essential tool in material science and chemical biology.
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