TCO-PEG8-NHS ester
This product is a heterobifunctional linker featuring a trans-cyclooctene (TCO) group for ultrafast tetrazine ligation and an NHS ester for efficient amine conjugation. The PEG8 spacer provides solubility, flexibility, and moderate spacing, making it especially valuable for probe development, ADCs, and multifunctional bioconjugation.
Key Features and Benefits:
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TCO Group: Enables rapid, copper-free IEDDA click chemistry with tetrazines.
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NHS Ester: Couples efficiently with primary amines under mild conditions.
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PEG8 Spacer: Provides hydrophilicity, solubility, and steric flexibility.
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Dual Reactivity: Combines click-ready and amine-targeted chemistry.
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High Purity: Ensures reproducibility in research and therapeutic workflows.
Applications:
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ADC Development: Provides PEGylated scaffolds for targeted drug conjugates.
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Probe Development: Builds TCO-modified probes for imaging and diagnostics.
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Bioconjugation: Supports multifunctional conjugation strategies with orthogonal reactivity.
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Drug Delivery: Enhances solubility and circulation of therapeutic conjugates.
Storage and Handling:
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Storage: Store at –20 °C in a sealed, moisture- and light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid NHS ester hydrolysis.
This product integrates ultrafast tetrazine ligation with amine-reactive chemistry in a PEG8 scaffold, providing solubility and dual reactivity specifically for advanced conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
