TCO-PEG8-amine
This product is a heterobifunctional linker featuring a trans-cyclooctene (TCO) group for ultrafast tetrazine ligation and a terminal amine for versatile conjugation. The PEG8 spacer improves solubility, hydrophilicity, and steric accessibility, making it especially effective for probe development, bioconjugation, and drug delivery.
Key Features and Benefits:
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TCO Group: Enables rapid, copper-free IEDDA click chemistry with tetrazines.
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Terminal Amine: Couples efficiently with activated esters and electrophiles.
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PEG8 Spacer: Enhances solubility, flexibility, and steric spacing.
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Dual Reactivity: Combines bioorthogonal and amine-targeted chemistry.
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High Purity: Ensures reproducibility in sensitive workflows.
Applications:
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Bioorthogonal Labeling: Supports ultrafast tetrazine ligation in vitro and in vivo.
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Probe Development: Builds TCO-modified probes for imaging and diagnostics.
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Drug Delivery: Provides PEGylated scaffolds with extended solubility.
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Bioconjugation: Supports multifunctional and orthogonal conjugation strategies.
Storage and Handling:
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Storage: Store at –20 °C in a sealed, moisture- and light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid prolonged light exposure to preserve TCO reactivity.
This product integrates ultrafast tetrazine ligation with amine conjugation in a PEG8 scaffold, specifically offering flexibility, solubility, and control for advanced conjugation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
