TCO-PEG7-amido maleimide
This product is a bifunctional PEG linker containing a trans-cyclooctene (TCO) group and a maleimide group connected via a PEG7 spacer. It enables bioorthogonal click reactions with tetrazines and selective thiol coupling, making it especially versatile for bioconjugation.
Key Features and Benefits
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TCO Group: Supports rapid inverse-electron-demand Diels–Alder (IEDDA) click reactions with tetrazines.
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Maleimide Group: Couples selectively with thiols to form stable thioether bonds.
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PEG7 Spacer: Provides solubility and reduces steric hindrance.
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Dual Functionality: Combines orthogonal click and thiol reactivity in one linker.
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High Purity: Ensures consistent performance in sensitive applications.
Applications
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Bioconjugation: Links thiol-containing biomolecules with tetrazine-functionalized partners.
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Probe Development: Builds dual-reactive probes for imaging and diagnostics.
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Drug Delivery: Provides PEGylated scaffolds for multifunctional drug conjugates.
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Material Science: Functionalizes surfaces and nanostructures with orthogonal chemistries.
Storage and Handling
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Storage: Keep at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO to preserve reactivity.
This product integrates TCO–tetrazine click reactivity with maleimide–thiol coupling in a PEG7 scaffold, specifically offering a powerful dual-functional linker for advanced conjugation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
