TCO-PEG4-amine
This product is a heterobifunctional linker featuring a trans-cyclooctene (TCO) group for ultrafast tetrazine ligation and a terminal amine for versatile conjugation. The PEG4 spacer enhances solubility, hydrophilicity, and spacing, making it especially ideal for bioorthogonal labeling, probe development, and drug delivery.
Key Features and Benefits:
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TCO Group: Reacts rapidly with tetrazines via copper-free IEDDA click chemistry.
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Terminal Amine: Couples with activated esters or electrophiles.
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PEG4 Spacer: Provides solubility, flexibility, and steric accessibility.
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Dual Reactivity: Supports bioorthogonal and amine-targeted workflows.
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High Purity: Ensures reproducibility in advanced applications.
Applications:
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Bioorthogonal Labeling: Enables ultrafast tetrazine ligation in vitro and in vivo.
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Probe Development: Builds TCO-functionalized probes for imaging and diagnostics.
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Drug Delivery: Supports PEGylated conjugates with long circulation.
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Bioconjugation: Combines amine reactivity with bioorthogonal ligation.
Storage and Handling:
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Storage: Store at –20 °C in a sealed, moisture- and light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid prolonged exposure to light.
This product integrates ultrafast bioorthogonal ligation with amine coupling in a PEG4 scaffold, specifically providing versatility for conjugation, drug delivery, and probe development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
