TCO-PEG3-oxyamine
This product is a high-purity PEG linker with a trans-cyclooctene (TCO) group and a terminal oxyamine, specifically connected by a PEG3 spacer for solubility and flexibility.
Key Features and Benefits
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TCO Group – Enables rapid and bioorthogonal click reactions with tetrazines.
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Oxyamine Group – Reacts selectively with aldehydes and ketones to form stable oxime linkages.
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PEG3 Spacer – Improves solubility, reduces steric hindrance, and enhances accessibility in conjugates.
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High Purity – Suitable for bioconjugation, labeling, and advanced chemical biology workflows.
Applications
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Dual-functional linker for orthogonal bioconjugation
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Site-specific protein, peptide, or antibody modification
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Oxime ligation with aldehyde/ketone-functionalized biomolecules
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Tetrazine–TCO ligation for rapid click chemistry in vitro and in vivo
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Development of imaging probes, drug delivery systems, and diagnostics
Storage & Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Use: Dissolve in anhydrous solvents (e.g., DMF, DMSO). Avoid repeated freeze–thaw cycles.
This product combines a TCO group for fast tetrazine ligation and an oxyamine for oxime formation, linked via a PEG3 spacer for solubility and reduced steric hindrance. This dual-functional linker is especially ideal for orthogonal bioconjugation and chemical biology applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
