TCO-PEG3-aldehyde
Product Overview
TCO-PEG3-aldehyde is a heterobifunctional linker featuring a TCO moiety for inverse electron demand Diels-Alder (IEDDA) cycloaddition reactions and an aldehyde group for oxime/hydrazone ligation. The TCO reacts rapidly with tetrazines to form stable dihydropyridazine linkages, enabling highly selective and efficient conjugation in complex biological systems, including live cells. This bioorthogonal reaction offers unparalleled speed, selectivity, and biocompatibility, making TCO-PEG3-aldehyde a versatile tool for imaging, therapeutic research, and diagnostics.
Features
- Dual Functional Groups: TCO for tetrazine ligation; aldehyde for oxime/hydrazone formation.
- Fast and Selective: Rapid conjugation in aqueous and complex environments.
- Bioorthogonal Reactivity: Highly selective reactions in functionalized biological systems.
- PEG3 Spacer: Enhances solubility and reduces steric hindrance.
- High Purity: ≥95% for reproducibility.
- Versatile Applications: Ideal for fluorescent imaging, drug delivery, and radiochemistry.
Applications
- Fluorescent and PET/SPECT Imaging: Site-specific labeling for diagnostics and research.
- Therapeutics: Synthesis of targeted drug delivery systems and radionuclide therapies.
- Bioconjugation: Modification of proteins, peptides, and antibodies.
- Chemical Biology: Reactivity in live cells and complex biological systems.
- Surface Immobilization: Functionalization of surfaces for biosensors and assays.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
