TCO-PEG2-oxyamine
This product is a bifunctional PEG linker containing a trans-cyclooctene (TCO) group, a PEG2 spacer, and a terminal oxyamine. It enables rapid tetrazine click chemistry and selective oxime ligation with aldehydes or ketones, specifically providing versatile dual reactivity.
Key Features and Benefits
-
TCO Group: Reacts rapidly with tetrazines via inverse-electron-demand Diels–Alder (IEDDA) click chemistry.
-
Oxyamine Group: Couples with aldehydes or ketones to form stable oxime bonds.
-
PEG2 Spacer: Enhances solubility while maintaining compact molecular size.
-
Dual Reactivity: Combines click and carbonyl-reactive chemistries in one linker.
-
High Purity: Ensures consistent results in bioconjugation workflows.
Applications
-
Bioconjugation: Links aldehyde- or ketone-modified biomolecules with tetrazine partners.
-
Probe Development: Builds multifunctional probes for imaging and diagnostics.
-
Drug Delivery: Serves as a scaffold for dual-functional therapeutic conjugates.
-
Material Science: Functionalizes surfaces and nanostructures with orthogonal chemistries.
Storage and Handling
-
Storage: Keep at –20 °C in a sealed, light- and moisture-protected container.
-
Handling: Use anhydrous solvents such as DMF or DMSO to preserve reactivity.
This product integrates TCO click reactivity with oxyamine–carbonyl conjugation in a PEG2 scaffold, specifically providing a compact and versatile tool for multifunctional conjugation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
