TCO-PEG2-maleimide
This product is a compact heterobifunctional linker that contains a trans-cyclooctene (TCO) group, a PEG2 spacer, and a maleimide functionality. The TCO provides ultrafast copper-free click chemistry with tetrazines, while the maleimide reacts selectively with thiols to form stable thioether bonds. The short PEG2 spacer specifically improves solubility and maintains a minimal distance for efficient conjugation.
Key Features and Benefits
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TCO Group: Enables rapid, copper-free click reactivity with tetrazines through inverse electron-demand Diels–Alder (IEDDA) chemistry.
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Maleimide Group: Selectively couples with thiols on cysteine residues to form stable linkages.
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PEG2 Spacer: Provides solubility and reduces steric hindrance while maintaining compact design.
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Dual Reactivity: Combines orthogonal click chemistry with thiol-specific conjugation.
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High Purity: Produced to ≥95% purity for reproducible performance.
Applications
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Bioconjugation: Links thiol-containing biomolecules with tetrazine-functionalized partners.
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Protein and Antibody Labeling: Allows site-specific conjugation through cysteine residues.
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Drug Delivery Research: Serves as a linker in targeted therapeutics and ADC design.
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Chemical Biology: Facilitates compact and efficient labeling strategies in biological systems.
Storage and Handling
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Storage: Store at –20 °C in a sealed container, protected from light and moisture.
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Handling: Dissolve freshly in dry solvent; avoid repeated freeze–thaw cycles.
This product combines a reactive TCO group with a thiol-specific maleimide, specifically offering a compact and efficient tool for bioorthogonal click chemistry and thiol conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
