TCO-PEG12-DBCO CAS: 2055022-06-3 is a bifunctional linker featuring trans-cyclooctene (TCO) and dibenzocyclooctyne (DBCO) groups, connected by a 12-unit polyethylene glycol (PEG) spacer. TCO is a highly reactive strained alkene, while DBCO is an efficient cycloaddition partner, forming stable and inert triazole rings. The PEG12 linker imparts solubility and reduces steric hindrance for improved bioconjugation.
In pharmaceutical research and development, TCO-PEG12-DBCO serves as an invaluable tool for bioorthogonal click chemistry. This linker enables rapid, selective, and biocompatible conjugation of biomolecules, such as proteins, peptides, and nucleic acids. With applications in drug delivery, bioimaging, and targeted therapies, TCO-PEG12-DBCO facilitates the development of advanced therapeutics with enhanced efficacy and minimal off-target effects.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
