TCO-PEG12-DBCO
This product is a heterobifunctional PEG linker containing a trans-cyclooctene (TCO) group, a PEG12 spacer, and a dibenzocyclooctyne (DBCO). It specifically enables rapid tetrazine ligation and copper-free click chemistry, offering solubility, long-chain flexibility, and dual orthogonal reactivity.
Key Features and Benefits
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TCO Group: Reacts rapidly with tetrazines via IEDDA bioorthogonal click chemistry.
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DBCO Group: Couples with azides through SPAAC copper-free click chemistry.
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PEG12 Spacer: Provides hydrophilicity, solubility, and extended spacing.
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Dual Orthogonal Handles: Enables two independent bioorthogonal reactions.
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High Purity: Ensures reproducibility in sensitive conjugation workflows.
Applications
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Bioconjugation: Links tetrazine- and azide-modified biomolecules.
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Probe Development: Builds multifunctional probes for diagnostics and imaging.
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Drug Delivery: Provides PEG scaffolds with dual bioorthogonal handles.
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Material Science: Functionalizes nanoparticles, polymers, and surfaces with orthogonal reactivity.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.
This product integrates TCO and DBCO bioorthogonal chemistries in a PEG12 scaffold, specifically offering solubility, flexibility, and versatile dual conjugation capability.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
