TCO-PEG1-OH (equatorial)
This high-purity PEG linker features an equatorial trans-cyclooctene (TCO) group for rapid, catalyst-free inverse electron-demand Diels–Alder (IEDDA) cycloaddition with tetrazines, and a terminal hydroxyl group for further chemical derivatization or conjugation. The short PEG1 spacer improves aqueous solubility, reduces steric hindrance, and maintains a compact structure, enabling especially efficient and orthogonal bioconjugation in both aqueous and organic systems.
Key Features and Benefits
-
Equatorial TCO Group – Enables ultra-fast, catalyst-free tetrazine ligation for bioorthogonal labeling.
-
Hydroxyl Group – Serves as a versatile handle for further functionalization or coupling.
-
PEG1 Spacer – Improves solubility while minimizing steric hindrance and maintaining a compact structure.
-
Orthogonal Reactivity – Supports sequential, site-specific modifications without cross-reactivity.
-
High Purity – Supplied at >95% purity for reliable, reproducible performance.
Applications
-
Protein, peptide, and antibody modification
-
Bioorthogonal probe and imaging agent synthesis
-
Precursor for multifunctional linker design
-
Site-specific drug delivery and conjugation strategies
Storage and Handling
-
Storage: Store at –20 °C, dry, and protected from light
-
Handling: Use anhydrous solvents such as DMSO or DMF; avoid moisture to preserve reactivity
This product links an equatorial TCO to a hydroxyl group via a short PEG1 spacer specifically for rapid tetrazine ligation and versatile derivatization with minimal steric hindrance.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
