TCO-carbonylamino-benzamido-PEG2 NHS ester
This product is a heterobifunctional linker featuring a trans-cyclooctene (TCO) group for ultrafast IEDDA ligation with tetrazines and an NHS ester for amine coupling. The PEG2 spacer enhances solubility and compact flexibility, making it especially ideal for multifunctional bioconjugation, probe design, and drug delivery.
Key Features and Benefits:
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TCO Group: Supports rapid, copper-free tetrazine ligation.
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NHS Ester: Couples efficiently with amines under mild conditions.
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PEG2 Spacer: Provides solubility and minimal steric hindrance.
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Dual Reactivity: Combines bioorthogonal click chemistry with amine conjugation.
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High Purity: Ensures reproducibility in advanced workflows.
Applications:
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Bioconjugation: Links amine- and tetrazine-containing biomolecules.
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Probe Development: Builds multifunctional probes for imaging and diagnostics.
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Drug Delivery: Provides PEGylated scaffolds with orthogonal handles.
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Synthetic Chemistry: Useful in modular and orthogonal linker design.
Storage and Handling:
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Storage: Store at –20 °C in a tightly sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid NHS ester hydrolysis.
This product integrates TCO-based bioorthogonal reactivity with amine-targeted conjugation in a PEG2 scaffold, specifically offering versatility for advanced conjugation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
